干细胞的标记与成像——前景与担忧
Labeling and Imaging of Stem Cells - Promises and Concerns.
作者信息
Schäfer Richard
机构信息
Institute of Clinical and Experimental Transfusion Medicine, University Hospital Tuebingen, Germany.
出版信息
Transfus Med Hemother. 2010 Apr;37(2):85-89. doi: 10.1159/000287271. Epub 2010 Mar 8.
Abstract
For experimental and clinical applications of stem cells cell labeling and tracking is interesting to evaluate cell distribution and homing. Tracking of cells after transplantation can be performed for monitoring the delivery and faith of the graft. Furthermore, imaging techniques are part of the evaluation of the functional effects of cellular therapy in the organism of the host. Therefore, systematic investigations on the development and clinical evaluation of imaging techniques and their possible biological impact on stem cells is an emerging topic of today's applied stem cell research. This article refers to different labeling techniques of stem cells highlighting their promises for clinical use and discussing their possible risks.
摘要
对于干细胞的实验和临床应用而言，细胞标记和追踪对于评估细胞分布和归巢很有意义。移植后对细胞进行追踪可用于监测移植物的递送和存活情况。此外，成像技术是评估细胞疗法对宿主机体功能影响的一部分。因此，对成像技术的发展及其对干细胞可能产生的生物学影响进行系统研究是当今应用干细胞研究中一个新兴的课题。本文介绍了干细胞的不同标记技术，强调了它们在临床应用中的前景，并讨论了其可能存在的风险。
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