利用磁共振成像对细胞疗法进行体内追踪。
In vivo tracking of cellular therapeutics using magnetic resonance imaging.
作者信息
Long Christoper M, Bulte Jeff W M
机构信息
The Johns Hopkins University, School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Baltimore, USA.
出版信息
Expert Opin Biol Ther. 2009 Mar;9(3):293-306. doi: 10.1517/14712590802715723.
Abstract
BACKGROUND
The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy.
OBJECTIVE
To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology.
METHODS
We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease.
RESULTS/CONCLUSION: New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.
摘要
背景
许多基于细胞的疗法的成功高度依赖于细胞治疗剂的准确递送、剂量和运输。体内磁共振（MR）细胞追踪提供了一种非侵入性且纵向评估细胞治疗这些参数的方法。
目的
概述MR细胞追踪以及如何通过利用该技术改善细胞治疗。
方法
我们重点关注疾病临床前模型中用于干细胞和免疫疗法的技术。
结果/结论：MR细胞追踪的新技术很快将使该领域超越临床前研究，并开始在新型实验性细胞疗法的临床试验中显示出益处。
相似文献
1
In vivo tracking of cellular therapeutics using magnetic resonance imaging.利用磁共振成像对细胞疗法进行体内追踪。
Expert Opin Biol Ther. 2009 Mar;9(3):293-306. doi: 10.1517/14712590802715723.
2
Imaging of stem cells using MRI.利用磁共振成像对干细胞进行成像。
Basic Res Cardiol. 2008 Mar;103(2):105-13. doi: 10.1007/s00395-008-0704-5.
3
Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use.磁共振成像跟踪铁氧体标记的人神经干细胞：临床应用相关研究。
Stem Cells Transl Med. 2013 Oct;2(10):766-75. doi: 10.5966/sctm.2013-0049. Epub 2013 Sep 6.
4
The present status of cell tracking methods in animal models using magnetic resonance imaging technology.使用磁共振成像技术在动物模型中进行细胞追踪方法的现状
Mol Cells. 2007 Apr 30;23(2):132-7.
5
Iron administration before stem cell harvest enables MR imaging tracking after transplantation.在干细胞采集前给予铁剂可实现移植后的磁共振成像追踪。
Radiology. 2013 Oct;269(1):186-97. doi: 10.1148/radiol.13130858. Epub 2013 Jul 12.
6
Tracking immune cells in vivo using magnetic resonance imaging.利用磁共振成像技术在体内追踪免疫细胞。
Nat Rev Immunol. 2013 Oct;13(10):755-63. doi: 10.1038/nri3531. Epub 2013 Sep 10.
7
Long-term MRI tracking of dual-labeled adipose-derived stem cells homing into mouse carotid artery injury.双标记脂肪来源干细胞归巢至小鼠颈动脉损伤的长期 MRI 跟踪。
Int J Nanomedicine. 2012;7:5191-203. doi: 10.2147/IJN.S35647. Epub 2012 Oct 2.
8
In vivo MRI cell tracking: clinical studies.体内磁共振成像细胞追踪：临床研究
AJR Am J Roentgenol. 2009 Aug;193(2):314-25. doi: 10.2214/AJR.09.3107.
9
Novel positively charged nanoparticle labeling for in vivo imaging of adipose tissue-derived stem cells.用于脂肪组织来源干细胞体内成像的新型带正电荷纳米颗粒标记
PLoS One. 2014 Nov 3;9(11):e110142. doi: 10.1371/journal.pone.0110142. eCollection 2014.
10
Poly (dopamine) coated superparamagnetic iron oxide nanocluster for noninvasive labeling, tracking, and targeted delivery of adipose tissue-derived stem cells.聚多巴胺包覆的超顺磁性氧化铁纳米簇用于脂肪组织来源干细胞的无创标记、追踪及靶向递送
Sci Rep. 2016 Jan 5;6:18746. doi: 10.1038/srep18746.
引用本文的文献
1
Engineering mRNA CAR-T Cells for Cancer Immunotherapy.用于癌症免疫治疗的工程化信使核糖核酸嵌合抗原受体T细胞
Methods Mol Biol. 2025;2965:285-321. doi: 10.1007/978-1-0716-4742-4_14.
2
Biohybrid Nanoparticle-Based In Situ Monitoring of In Vivo Drug Delivery.基于生物杂交纳米粒子的体内药物递释原位监测。
Biosensors (Basel). 2023 Dec 6;13(12):1017. doi: 10.3390/bios13121017.
3
Application of magnetic nanoparticles in cell therapy.磁性纳米颗粒在细胞治疗中的应用。
Stem Cell Res Ther. 2022 Apr 1;13(1):135. doi: 10.1186/s13287-022-02808-0.
4
In vivo imaging of nanoparticle-labeled CAR T cells.体内纳米颗粒标记的 CAR T 细胞成像。
Proc Natl Acad Sci U S A. 2022 Feb 8;119(6). doi: 10.1073/pnas.2102363119.
5
Molecular imaging in tracking cancer stem cells: A review.追踪癌症干细胞中的分子成像：综述
Med J Islam Repub Iran. 2020 Aug 3;34:90. doi: 10.34171/mjiri.34.90. eCollection 2020.
6
In vivo Cell Tracking Using Non-invasive Imaging of Iron Oxide-Based Particles with Particular Relevance for Stem Cell-Based Treatments of Neurological and Cardiac Disease.基于氧化铁粒子的非侵入性成像的体内细胞示踪及其在神经和心脏疾病的基于干细胞的治疗中的特殊相关性。
Mol Imaging Biol. 2020 Dec;22(6):1469-1488. doi: 10.1007/s11307-019-01440-4.
7
Integrating a 19F MRI Tracer Agent into the Clinical Scale Manufacturing of a T-Cell Immunotherapy.将 19F MRI 示踪剂整合到 T 细胞免疫疗法的临床规模生产中。
Contrast Media Mol Imaging. 2017 Nov 2;2017:9548478. doi: 10.1155/2017/9548478. eCollection 2017.
8
The Protein Corona around Nanoparticles Facilitates Stem Cell Labeling for Clinical MR Imaging.纳米颗粒周围的蛋白质冠层有助于用于临床磁共振成像的干细胞标记。
Radiology. 2018 Mar;286(3):938-947. doi: 10.1148/radiol.2017170130. Epub 2017 Nov 1.
9
Encapsulated Islet Transplantation: Where Do We Stand?封装胰岛移植：我们目前的进展如何？
Rev Diabet Stud. 2017 Spring;14(1):51-78. doi: 10.1900/RDS.2017.14.51. Epub 2017 Jun 12.
10
Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography.纳米颗粒造影剂在计算机断层扫描细胞追踪中的应用。
Bioconjug Chem. 2017 Jun 21;28(6):1581-1597. doi: 10.1021/acs.bioconjchem.7b00194. Epub 2017 May 18.
本文引用的文献
1
In Vivo Tracking of Human Mesenchymal Stem Cells in Experimental Stroke.实验性中风中人间充质干细胞的体内追踪
Cell Transplant. 2007 Nov;16(10):1007-1012. doi: 10.3727/000000007783472381.
2
In vivo "hot spot" MR imaging of neural stem cells using fluorinated nanoparticles.使用氟化纳米颗粒对神经干细胞进行体内“热点”磁共振成像。
Magn Reson Med. 2008 Dec;60(6):1506-11. doi: 10.1002/mrm.21783.
3
New "multicolor" polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI.用于磁共振成像（MRI）的新型“多色”多肽抗磁性化学交换饱和转移（DIACEST）造影剂。
Magn Reson Med. 2008 Oct;60(4):803-12. doi: 10.1002/mrm.21683.
4
Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis.人胚胎干细胞源性神经前体细胞移植在多发性硬化动物模型中的神经保护作用
PLoS One. 2008 Sep 5;3(9):e3145. doi: 10.1371/journal.pone.0003145.
5
Dendritic cell vaccination and immune monitoring.树突状细胞疫苗接种与免疫监测。
Cancer Immunol Immunother. 2008 Oct;57(10):1559-68. doi: 10.1007/s00262-008-0553-y. Epub 2008 Jul 10.
6
Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction.在心肌梗死小鼠模型中对氧化铁标记的胚胎干细胞源性心脏前体细胞进行的系列体内阳性对比磁共振成像。
Magn Reson Med. 2008 Jul;60(1):73-81. doi: 10.1002/mrm.21642.
7
MR tracking of transplanted cells with "positive contrast" using manganese oxide nanoparticles.使用氧化锰纳米颗粒通过“阳性对比剂”对移植细胞进行磁共振追踪。
Magn Reson Med. 2008 Jul;60(1):1-7. doi: 10.1002/mrm.21622.
8
Micro-engineered local field control for high-sensitivity multispectral MRI.用于高灵敏度多光谱磁共振成像的微工程局部场控制
Nature. 2008 Jun 19;453(7198):1058-63. doi: 10.1038/nature07048.
9
MagA is sufficient for producing magnetic nanoparticles in mammalian cells, making it an MRI reporter.MagA足以在哺乳动物细胞中产生磁性纳米颗粒，使其成为一种磁共振成像报告分子。
Magn Reson Med. 2008 Jun;59(6):1225-31. doi: 10.1002/mrm.21606.
10
Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia.短暂性缺血后间充质干细胞靶向动脉内递送的双模态监测
Stroke. 2008 May;39(5):1569-74. doi: 10.1161/STROKEAHA.107.502047. Epub 2008 Mar 6.
Zotero 插件