Samoĭlova Z T, Klimenko V V, Khaliutina L V, Laz'ko S M
Biull Eksp Biol Med. 1978 Apr;85(4):412-4.
In experiments on mongrel rats it was found that heparin in doses of 2, 5, and 10 mg/kg had an inducing effect on the oxidative systems of hepatic microsomes: hexenal test period was shortened, cytochrome P450 content increased, relative liver weight rose; the activity of histochemically-detectable NAD-enzymes of hepatocytes became greater. Heparin was capable of considerable (2-3-fold) stimulation of antitoxic activity of the liver reduced in experimental glomerulonephritis. The effect of heparin on the antitoxic function of the liver did not correlate with its effect, on the blood coagulation system.
在对杂种大鼠的实验中发现，2、5和10毫克/千克剂量的肝素对肝微粒体的氧化系统有诱导作用：己烯醛测试期缩短，细胞色素P450含量增加，肝脏相对重量上升；肝细胞中组织化学可检测的NAD酶活性增强。肝素能够显著（2至3倍）刺激实验性肾小球肾炎中降低的肝脏解毒活性。肝素对肝脏解毒功能的影响与其对血液凝固系统的影响无关。
