Saratikov A S, Novozheeva T P, Vengerovskiĭ A I
Vopr Med Khim. 1983 Mar-Apr;29(2):23-6.
An anticonvulsive drug benzobamil (3-benzoyl-5-ethyl-5-isoamyl barbituric acid) improved the antitoxic function of liver tissue, increased the content of RNA, protein, cytochrome P-450, accelerated the oxidation of NADH, NADPH as well as metabolism of xenobiotics in microsomes of rats with CCl4 intoxication. Benzobamil normalized the hepatocyte structure, corrected the fatty dystrophy, stimulated the protein synthesis, increased the content of glycogen as well as activity of succinate and lactate dehydrogenases and stabilized the lysosomal membranes.
抗惊厥药物苯佐巴比妥（3-苯甲酰基-5-乙基-5-异戊基巴比妥酸）改善了肝组织的解毒功能，增加了RNA、蛋白质、细胞色素P-450的含量，加速了四氯化碳中毒大鼠微粒体中NADH、NADPH的氧化以及外源化合物的代谢。苯佐巴比妥使肝细胞结构正常化，纠正了脂肪营养不良，刺激了蛋白质合成，增加了糖原含量以及琥珀酸和乳酸脱氢酶的活性，并稳定了溶酶体膜。
