[Effect of benzobamil on the morpho-functional state of liver and drug metabolism in experimental CC14 intoxication].

An anticonvulsive drug benzobamil (3-benzoyl-5-ethyl-5-isoamyl barbituric acid) improved the antitoxic function of liver tissue, increased the content of RNA, protein, cytochrome P-450, accelerated the oxidation of NADH, NADPH as well as metabolism of xenobiotics in microsomes of rats with CCl4 intoxication. Benzobamil normalized the hepatocyte structure, corrected the fatty dystrophy, stimulated the protein synthesis, increased the content of glycogen as well as activity of succinate and lactate dehydrogenases and stabilized the lysosomal membranes.