Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Post Office Box 30001, 9700 RB Groningen, The Netherlands.
Head Neck. 2011 Jun;33(6):863-70. doi: 10.1002/hed.21546. Epub 2010 Aug 24.
The purpose of this study was to test whether nutritional status of patients with head and neck cancer changes during and after treatment.
Nutritional status (including body weight, lean mass, and fat mass) and dietary intake were assessed in 29 patients with head and neck cancer. Patients were assessed 1 week before, and 1 and 4 months after treatment (radiotherapy, either alone or combined with chemotherapy or surgery).
During treatment, body weight (-3.6 ± 5.3 kg; p = .019) and lean mass (-2.43 ± 2.81 kg; p = .001) significantly declined. Patients with sufficient intake (≥35 kcal and ≥1.5 grams protein/kg body weight) lost less body weight and lean mass than patients with insufficient intake (mean difference, -4.0 ± 1.9 kg; p = 0.048 and -2.1 ± 1.0 kg; p = .054, respectively). After treatment, only patients with sufficient intake gained body weight (2.3 ± 2.3 kg) and lean mass (1.2 ± 1.3 kg).
Patients with head and neck cancer fail to maintain or improve nutritional status during treatment, despite sufficient intake.
本研究旨在测试头颈部癌症患者在治疗期间和治疗后其营养状况是否发生变化。
对 29 例头颈部癌症患者的营养状况（包括体重、瘦体重和体脂肪量）和饮食摄入量进行评估。患者在治疗前 1 周、治疗后 1 个月和 4 个月进行评估（单独放疗、联合化疗或手术）。
治疗期间，体重（-3.6 ± 5.3 kg；p =.019）和瘦体重（-2.43 ± 2.81 kg；p =.001）明显下降。摄入充足（≥35 千卡和≥1.5 克蛋白质/公斤体重）的患者比摄入不足的患者体重和瘦体重丢失少（平均差值，-4.0 ± 1.9 kg；p = 0.048 和-2.1 ± 1.0 kg；p = 0.054）。治疗后，仅摄入充足的患者体重（2.3 ± 2.3 kg）和瘦体重（1.2 ± 1.3 kg）增加。
尽管摄入充足，但头颈部癌症患者在治疗期间无法维持或改善其营养状况。
