Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, Brazil.
Phytother Res. 2011 Mar;25(3):444-50. doi: 10.1002/ptr.3274. Epub 2010 Aug 25.
Justicia pectoralis (Acanthaceae) is used as an antiinflammatory, antimicrobial and bronchodilator, and its extract exerts an anxiolytic-like effect profile in animal models. This work presents the behavioral effects of an aqueous standardized extract of Justicia pectoralis (SEJP) in animal models, such as the elevated plus maze (EPM), light/dark, open field, rota rod and pentobarbital sleep time. The extract was administered intragastrically to male mice at single doses of 50, 100 and 200 mg/kg, while diazepam 1 or 2 mg/kg was used as a standard drug and flumazenil 2.5 mg/kg was used to evaluate the participation of benzodiazepinic receptors. The results showed that, similar to diazepam (1 mg/kg), SEJP significantly modified all the observed parameters in the EPM test, without altering the general motor activity in the open field, rota rod and pentobarbital sleep time tests. Flumazenil reversed not only the diazepam effect but also the SEJP effect. In the same way, all doses of SEJP increased the time of permanence in the light box in the light/dark test. The results showed that SEJP presented an anxiolytic-like effect, disproving sedative effects.
尖瓣鱼木（爵床科）被用作抗炎、抗菌和支气管扩张剂，其提取物在动物模型中表现出类似抗焦虑的作用模式。本工作介绍了尖瓣鱼木水提标准化提取物（SEJP）在动物模型中的行为效应，如高架十字迷宫（EPM）、明暗、旷场、转棒和戊巴比妥睡眠时间。提取物以 50、100 和 200 mg/kg 的单剂量灌胃给予雄性小鼠，而地西泮 1 或 2 mg/kg 被用作标准药物，氟马西尼 2.5 mg/kg 用于评估苯二氮䓬受体的参与。结果表明，与地西泮（1 mg/kg）相似，SEJP 显著改变了 EPM 测试中观察到的所有参数，而不改变旷场、转棒和戊巴比妥睡眠时间测试中的一般运动活动。氟马西尼不仅逆转了地西泮的作用，也逆转了 SEJP 的作用。同样，SEJP 的所有剂量都增加了明暗测试中在亮箱中的停留时间。结果表明，SEJP 表现出类似抗焦虑的作用，否定了镇静作用。
