C.N.R. Neuroscience Institute, Cagliari (CA), Italy.
Phytother Res. 2011 Mar;25(3):463-6. doi: 10.1002/ptr.3285. Epub 2010 Aug 25.
Several recent preliminary clinical studies have suggested that artichoke (Cynara scolymus L., Asteraceae family) preparations may be capable of lowering post-prandial glycemia. The present study was designed to test this hypothesis in laboratory rats. To this aim, non-selected Wistar and genetically obese Zucker rats were treated acutely with a purified extract of Cynara scolymus flowering heads (500-1500 mg/kg by gavage) immediately prior to 1 h access to a fixed amount of food. Glycemia was recorded 60, 120 and 360 min after food presentation. Treatment with Cynara scolymus flowering head extract resulted in a significant decrease of post-prandial glycemia in both rat strains. The lack of any fiber content in this Cynara scolymus flowering head extract excludes the involvement of dietary fibers in glycemia reduction. The results obtained constitute the first evidence of a hypoglycemic effect of an artichoke preparation in laboratory rodents and confirm previous observations made in humans.
几项最近的初步临床研究表明，朝鲜蓟（朝鲜蓟，菊科）制剂可能能够降低餐后血糖。本研究旨在实验室大鼠中检验这一假设。为此，非选择性 Wistar 和遗传性肥胖 Zucker 大鼠在 1 小时固定食物摄入量前通过灌胃给予朝鲜蓟花头的纯化提取物（500-1500mg/kg）进行急性处理。在进食后 60、120 和 360 分钟记录血糖。朝鲜蓟花头提取物处理导致两种大鼠的餐后血糖显著降低。这种朝鲜蓟花头提取物中缺乏任何纤维含量排除了膳食纤维在降低血糖中的作用。所得结果构成了朝鲜蓟制剂在实验室啮齿动物中具有降血糖作用的第一个证据，并证实了以前在人类中观察到的结果。
