与抗甲状腺抗体相关的类固醇反应性脊髓神经病。
Steroid-responsive myeloneuropathy associated with antithyroid antibodies.
作者信息
Turkoglu Recai, Tuzun Erdem
机构信息
Department of Neurology, Haydarpasa Numune State Hospital, Istanbul, Turkey.
出版信息
J Spinal Cord Med. 2010;33(3):278-80. doi: 10.1080/10790268.2010.11689708.
BACKGROUND/OBJECTIVE: To present information about 2 steroid-responsive, antithyroid antibody-positive patients with myeloneuropathy and myelopathy.
METHODS
Case reports.
RESULTS
A 48-year-old woman and a 42-year-old man presented with acute onset tetraparesis and magnetic resonance imaging studies showing cervical spinal lesions. Nerve conduction and biopsy studies of the woman were suggestive of a demyelinating polyradiculoneuropathy. Detailed diagnostic workup turned out to be negative for both patients, except for highly elevated antithyroid antibodies with normal thyroid functions and imaging. Both patients responded remarkably well to high-dose steroid treatment, and their symptoms disappeared in a few months. Both patients' antithyroid antibody levels were reduced shortly after steroid treatment and in parallel with the amelioration of symptoms.
CONCLUSIONS
Antithyroid antibodies might be associated with acute demyelinating myeloneuropathy or myelopathy pathogenesis and might indicate a good response to steroid treatment in these syndromes.
背景/目的：介绍2例患有骨髓神经病和脊髓病的类固醇反应性、抗甲状腺抗体阳性患者的情况。
方法
病例报告。
结果
一名48岁女性和一名42岁男性出现急性四肢轻瘫，磁共振成像显示颈椎脊髓病变。对该女性进行的神经传导和活检研究提示为脱髓鞘性多发性神经根神经病。除甲状腺功能正常但抗甲状腺抗体高度升高及影像学检查外，两名患者的详细诊断检查结果均为阴性。两名患者对高剂量类固醇治疗反应显著良好，症状在数月内消失。类固醇治疗后不久，两名患者的抗甲状腺抗体水平均降低，且与症状改善同步。
结论
抗甲状腺抗体可能与急性脱髓鞘性骨髓神经病或脊髓病的发病机制有关，并且可能表明这些综合征对类固醇治疗反应良好。
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