Thimann Laboratories, University of California, Santa Cruz, California 95064, USA.
Dev Biol. 1981 Jun;84(2):465-70. doi: 10.1016/0012-1606(81)90416-4.
A temperature-sensitive mutant strain (shibire) has been used to probe the normal developmental process in Drosophila melanogaster. At high temperatures lethality occurs during embryonic development. Heat pulses given early disrupt cellular blastoderm formation in these mutants. Even in the absence of cells, the embryo begins morphogenetic movements characteristic of gastrulation. With heat pulses given later, the embryonic cells proliferate without normal differentiation.
一种温度敏感型突变株（shibire）已被用于探测黑腹果蝇的正常发育过程。在高温下，胚胎发育过程中会发生致死。在这些突变体中，早期给予热脉冲会破坏细胞胚层的形成。即使没有细胞，胚胎也会开始具有原肠胚形成特征的形态发生运动。后期给予热脉冲，胚胎细胞会增殖而没有正常的分化。
