A retrovirus expressing v-abl and c-myc induces plasmacytomas in 100% of adult pristane-primed BALB/c mice. - Suppr | 超能文献

A retrovirus expressing v-abl and c-myc induces plasmacytomas in 100% of adult pristane-primed BALB/c mice.

作者信息

Weissinger E M, Largaespada D, Smith-Gill S J, Risser R, Mushinski J F, Mischak H

机构信息

Laboratory of Genetics, National Cancer Institute, NIH, Bethesda, MD 20892.

出版信息

Curr Top Microbiol Immunol. 1990;166:121-7. doi: 10.1007/978-3-642-75889-8_16.

DOI:10.1007/978-3-642-75889-8_16

Abstract

摘要

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A retrovirus expressing v-abl and c-myc induces plasmacytomas in 100% of adult pristane-primed BALB/c mice.

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Rapid induction of plasmacytomas in mice by pristane and a murine recombinant retrovirus containing an avian v-myc and a defective raf oncogene.通过 pristane 和一种含有禽 v-myc 和缺陷型 raf 癌基因的鼠重组逆转录病毒在小鼠中快速诱导浆细胞瘤。

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Overexpression of v-abl uniquely cooperates with c-myc dysregulation in induction of plasma cell tumors, bypassing the need for T-lymphocytic help and overcoming T-lymphocytic interference.v-abl的过表达在浆细胞瘤的诱导中独特地与c-myc失调协同作用，绕过了对T淋巴细胞辅助的需求并克服了T淋巴细胞的干扰。

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Molecular requirements for rapid plasmacytoma and pre-B lymphoma induction by Abelson murine leukemia virus in myc-transgenic mice.阿贝尔逊鼠白血病病毒在myc转基因小鼠中快速诱导浆细胞瘤和前B淋巴瘤的分子要求。

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The ABL-MYC retrovirus generates antigen-specific plasmacytomas by in vitro infection of activated B lymphocytes from spleen and other murine lymphoid organs.

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Nonrandom chromosomal change (trisomy 11) in murine plasmacytomas induced by an ABL-MYC retrovirus.由ABL-MYC逆转录病毒诱导的鼠浆细胞瘤中的非随机染色体变化（三体11）

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A retrovirus that expresses v-abl and c-myc oncogenes rapidly induces plasmacytomas.一种表达v-abl和c-myc癌基因的逆转录病毒能快速诱导浆细胞瘤。

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Synergy of an IgH promoter-enhancer-driven c-myc/v-Ha-ras retrovirus and pristane in the induction of murine plasmacytomas.免疫球蛋白重链（IgH）启动子-增强子驱动的c-myc/v-Ha-ras逆转录病毒与 pristane 在诱导小鼠浆细胞瘤中的协同作用。

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Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus.用 pristane 和免疫球蛋白重链启动子/增强子驱动的 c-myc/v-Ha-ras 逆转录病毒快速诱导分泌 IgM 的小鼠浆细胞瘤

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The accelerating role of Abelson murine leukemia virus in murine plasmacytoma development: in vitro infection of spleen cells generates donor-type tumors after transfer to pristane-treated BALB/c mice.阿贝尔逊鼠白血病病毒在鼠浆细胞瘤发生中的加速作用：脾细胞的体外感染在转移至经 pristane 处理的 BALB/c 小鼠后产生供体类型的肿瘤。

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引用本文的文献

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Addition of constitutive c-myc expression to Abelson murine leukemia virus changes the phenotype of the cells transformed by the virus from pre-B-cell lymphomas to plasmacytomas.将组成型c-myc表达添加到艾贝尔森鼠白血病病毒中，会使该病毒转化的细胞表型从前B细胞淋巴瘤转变为浆细胞瘤。

Mol Cell Biol. 1993 Apr;13(4):2578-85. doi: 10.1128/mcb.13.4.2578-2585.1993.

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Induction of plasmacytomas secreting antigen-specific monoclonal antibodies with a retrovirus expressing v-abl and c-myc.

Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8735-9. doi: 10.1073/pnas.88.19.8735.