Guan Jing, Ni Daofeng, Wang Jian, Zhu Yingying, Xu Chunxiao, Chien Xingming, Liu Jianfeng
Department of Otolaryngology, Peking Union Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Jun;24(11):484-8.
To observe the effect of intranasal jet nebulizing inhalation with budesonide suspension on 20 patients with olfactory disorder due to upper respiratory tract infections (URTI) or nasal and accessory nasal diseases.
We tested the twenty patients with upper respiratory infection, naso sinusitis, allergic rhinitis, olfactory cleft disease induced olfactory loss by medical history, physical examination, olfactory tests and medical imaging. Budesonide suspension doses of 1 mg daily was administered by means of intranasal nebulization for 15 days. Olfactory function was assessed by T&T Olfactometry and olfactory event-related potentials before and after treatment, and only T&T Olfactometry was used after every 5 times for inhalation of budesonide.
Of the patients with olfactory disorder, olfactory function was recovered in 90% after the course of treatment, including cured in 25%, improved in 50%, and slightly improved in 15%. And apparent effect was observed to appeared mostly after nebulizing inhalation for 10 times.
The above findings suggest that intranasal nebulizing inhalation with budesonide may be an effective therapy in the treatment of URTI-related or nasal and accessory nasal diseases related olfactory disorder. It is worth using the therapy.
观察布地奈德混悬液经鼻喷射雾化吸入对20例因上呼吸道感染（URTI）或鼻及鼻窦疾病所致嗅觉障碍患者的疗效。
我们通过病史、体格检查、嗅觉测试和医学影像检查，对20例上呼吸道感染、鼻窦炎、过敏性鼻炎、嗅裂疾病所致嗅觉减退患者进行了检测。采用布地奈德混悬液1mg，每日经鼻雾化给药，疗程15天。治疗前后采用T&T嗅觉计和嗅觉事件相关电位评估嗅觉功能，每次布地奈德雾化吸入5次后仅使用T&T嗅觉计进行评估。
嗅觉障碍患者经治疗后，90%嗅觉功能恢复，其中治愈25%，好转50%，稍有改善15%。雾化吸入10次后大多出现明显效果。
上述结果表明，布地奈德经鼻雾化吸入可能是治疗URTI相关或鼻及鼻窦疾病相关嗅觉障碍的有效疗法。值得应用该疗法。
