中药对病毒感染后嗅觉功能障碍的影响：一项系统评价与Meta分析
The Effect of Traditional Chinese Medicine on Postviral Olfactory Dysfunction: A Systematic Review and Meta-Analysis.
作者信息
Ma Fangfang, Zhang Hewei, Li Bingxue, Yang Duanhong, Cheng Peiyu, Yu Mingwei, Dai Dechun, Li Xun, Wang Xiaomin
机构信息
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
Department of Acupuncture-Moxibustion, Tuina and Rehabilitation, Kunshan Hospital of Traditional Chinese Medicine, Kunshan 215300, Jiangsu, China.
出版信息
Evid Based Complement Alternat Med. 2023 Jan 18;2023:7448034. doi: 10.1155/2023/7448034. eCollection 2023.
OBJECTIVE
The aim of this study is to evaluate the efficacy and safety of traditional Chinese medicine (TCM) for postviral olfactory dysfunction (PVOD).
METHODS
PubMed, EMBASE, Cochrane Central Register of Controlled Trials, China Network Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Chinese Biomedical and Medical (CBM) Database, and Wanfang Database were electronically searched from their inception to July 25, 2022. Two authors independently performed study selection, data extraction, and quality assessment to ensure systematic quality evaluation. Randomized controlled trials (RCTs) comparing TCM with olfactory training and/or drug therapy (OTDT) were included. The outcomes were the effective rate, QOD-P, TDI score, UPSIT score, and adverse effects. Cochrane RoB was the guideline used to evaluate the methodological quality of the included trials. RevMan 5.3 software was used for statistical analysis.
RESULTS
A total of 6 RCTs involving 467 patients with PVOD were selected. Compared with OTDT, TCM plus OTDT decreased QOD-P (MD = -1.73, 95% CI (-2.40, -1.06), < 0.0001) but did not increase the effective rate (T&T) (RR = 1.28, 95% CI (0.86, 1.90), =0.22, = 61%). Compared with no treatment, TCM seemed to increase the treatment success rate (UPSIT) (RR = 3.17, 95% CI (1.78, 5.65), < 0.0001, = 0%), but there was no statistically significant difference in improving the UPSIT score (MD = 3.44, 95% CI (-1.36, 8.24), =0.16). Compared with drug therapy, TCM plus drug therapy appeared to increase the effective rate (ΔVAS) (RR = 2.36, 95% CI (1.41, 3.94), = 0%), but there was no statistically significant difference in improving the TDI score (MD = 2.10, 95% CI (-1.99, 6.19), =0.31). No significant differences in adverse reactions were reported between TCM and OTDT.
CONCLUSION
TCM may be an effective treatment for PVOD. With a lack of high-quality RCTs, further large-scale and high-quality RCTs are still warranted.
目的
本研究旨在评估中药治疗病毒感染后嗅觉功能障碍（PVOD）的疗效和安全性。
方法
对PubMed、EMBASE、Cochrane对照试验中央注册库、中国知网（CNKI）、维普中文科技期刊数据库（VIP）、中国生物医学文献数据库（CBM）和万方数据库进行电子检索，检索时间从建库至2022年7月25日。由两名作者独立进行研究筛选、数据提取和质量评估，以确保系统的质量评价。纳入比较中药与嗅觉训练和/或药物治疗（OTDT）的随机对照试验（RCT）。观察指标为有效率、嗅觉障碍量化评分（QOD-P）、嗅觉障碍残疾指数（TDI）评分、宾夕法尼亚大学嗅觉识别测试（UPSIT）评分及不良反应。采用Cochrane偏倚风险评估工具（Cochrane RoB）评估纳入试验的方法学质量。使用RevMan 5.3软件进行统计分析。
结果
共纳入6项RCT，涉及467例PVOD患者。与OTDT相比，中药联合OTDT可降低QOD-P（MD = -1.73，95%CI（-2.40，-1.06），P < 0.0001），但未提高有效率（T&T）（RR = 1.28，95%CI（0.86，1.90），P = 0.22，I² = 61%）。与未治疗相比，中药似乎可提高治疗成功率（UPSIT）（RR = 3.17，95%CI（1.78，5.65），P < 0.0001，I² = 0%），但在改善UPSIT评分方面无统计学显著差异（MD = 3.44，95%CI（-1.36，8.24），P = 0.16）。与药物治疗相比，中药联合药物治疗似乎可提高有效率（ΔVAS）（RR = 2.36，95%CI（1.41，3.94），I² = 0%），但在改善TDI评分方面无统计学显著差异（MD = 2.10，95%CI（-1.99，6.19），P = 0.31）。中药与OTDT在不良反应方面未报告有显著差异。
结论
中药可能是治疗PVOD的有效方法。由于缺乏高质量的RCT，仍需要进一步开展大规模、高质量的RCT。
Zotero 插件