Groupe Hospitalier Pitié-Salpêtrière, Service de Neurologie Mazarin, bâtiment Mazarin 47 bd de I'hôpital, 75013, Paris, France.
Adv Exp Med Biol. 2010;678:86-95. doi: 10.1007/978-1-4419-6306-2_12.
The existence of chemo brain has become almost universally accepted, although many details of the concept are controversial. Data about the different types of cognitive impairment and their duration are not always consistent in the literature. We still do not know which cytotoxic agents are responsible, which characteristics make patients vulnerableand which biologic mechanisms are involved. This chapter reviews the recent literature and provides an actualized definition of chemo brain, including recent functional imaging data and discusses its controversial aspects. Potential underlying mechanisms and their future possible clinical applications in the prevention and treatment of chemo brain are also discussed. These issues are of clinical importance given the prevalence of breast carcinoma, the increased use of chemotherapy as adjuvant therapy, the increasing use of more aggressive dosing schedules and the increasing survival rates. Better-designed future trials should lead to a better definition and understanding of chemo brain and to future therapies.
化疗脑的存在几乎已被普遍接受，尽管该概念的许多细节仍存在争议。文献中关于不同类型认知障碍及其持续时间的数据并不总是一致的。我们仍不知道哪些细胞毒性药物是罪魁祸首，哪些特征使患者易患这种疾病，以及涉及哪些生物学机制。本章回顾了最新的文献，并提供了化疗脑的一个最新定义，包括最近的功能成像数据，并讨论了其有争议的方面。还讨论了潜在的潜在机制及其在预防和治疗化疗脑方面的未来可能的临床应用。鉴于乳腺癌的高发率、辅助化疗的广泛应用、更积极的剂量方案的日益使用以及生存率的提高，这些问题具有重要的临床意义。更好设计的未来试验应能更好地定义和理解化疗脑，并为未来的治疗方法提供依据。
