Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, USA.
Adv Exp Med Biol. 2010;678:124-32. doi: 10.1007/978-1-4419-6306-2_16.
Pharmacokinetics of anticancer drugs used in breast cancer therapy are well established. This chapter reviews preclinical and clinical pharmacokinetics of the following drugs: cyclophosphamide, docetaxel, doxorubicin, 5-fluorouracil, methotrexate and tamoxifen. The absorption, distribution, metabolism and elimination of drugs are discussed in the context of breast cancer. The effect of age and menopause status on drug pharmacokinetics is evaluated. The important role of pharmacokinetic-pharmacodynamic modeling in understanding the phenomenon of chemo fog, memory deficit in breast cancer chemotherapy, is explored.
用于乳腺癌治疗的抗癌药物的药代动力学已得到充分确立。本章综述了以下药物的临床前和临床药代动力学：环磷酰胺、多西他赛、多柔比星、5-氟尿嘧啶、甲氨蝶呤和他莫昔芬。讨论了药物在乳腺癌中的吸收、分布、代谢和消除。评估了年龄和绝经状态对药物药代动力学的影响。探讨了药代动力学-药效学建模在理解化疗雾、乳腺癌化疗记忆缺陷现象中的重要作用。
