SCES's Indira College of Pharmacy, Tathwade, Pune, India.
Pharm Biol. 2010 Dec;48(12):1371-5. doi: 10.3109/13880209.2010.483248. Epub 2010 Aug 25.
The whole plant of Sphaeranthus indicus Linn. (Asteraceae) is traditionally used in the treatment of diabetes mellitus.
The present study investigated the effect of the methanol extract of Sphaeranthus indicus whole plant in dexamethasone-induced insulin resistance in mice.
The mice were treated with dexamethasone for 22 days and effects on plasma glucose level, serum triglyceride level, glucose uptake, levels of hepatic enzymes like glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), lipid peroxidase (LPO), and body weight was observed.
The Sphaeranthus indicus extract (SI) showed significant decrease in plasma glucose and serum triglyceride levels (p <0.01) at doses, of 400 and 800 mg/kg, p.o., and stimulated insulin assisted and non-insulin assisted glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and CAT were significantly increased (p <0.01) and there was a significant decrease in level of LPO (p <0.01). SI significantly restored (p <0.01) dexamethasone induced body weight loss.
Sphaeranthus indicus may prove to be effective in the treatment of type II diabetes mellitus owing to its ability to decrease insulin resistance.
全株南非叶（菊科）传统上用于治疗糖尿病。
本研究旨在探讨南非叶全株甲醇提取物对地塞米松诱导的胰岛素抵抗小鼠的影响。
将小鼠用地塞米松处理 22 天，观察血浆葡萄糖水平、血清三酰甘油水平、葡萄糖摄取、肝酶如谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、脂质过氧化物（LPO）和体重的变化。
南非叶提取物（SI）在 400 和 800mg/kg 剂量下，口服给药，可显著降低血浆葡萄糖和血清三酰甘油水平（p<0.01），并刺激骨骼肌胰岛素辅助和非胰岛素辅助葡萄糖摄取。抗氧化酶 GSH、SOD 和 CAT 的水平显著升高（p<0.01），LPO 的水平显著降低（p<0.01）。SI 还显著恢复了地塞米松诱导的体重减轻（p<0.01）。
南非叶可能因其降低胰岛素抵抗的能力而在治疗 II 型糖尿病方面有效。
