Department of Basic Psychology, Campus Bellvitge, University of Barcelona, 08035 Barcelona, Spain.
J Neurosci. 2010 Aug 25;30(34):11398-402. doi: 10.1523/JNEUROSCI.0111-10.2010.
Many aspects of human behavior are driven by rewards, yet different people are differentially sensitive to rewards and punishment. In this study, we show that white matter microstructure in the uncinate/inferior fronto-occipital fasciculus, defined by fractional anisotropy values derived from diffusion tensor magnetic resonance images, correlates with both short-term (indexed by the fMRI blood oxygenation level-dependent response to reward in the nucleus accumbens) and long-term (indexed by the trait measure sensitivity to punishment) reactivity to rewards. Moreover, trait measures of reward processing were also correlated with reward-related functional activation in the nucleus accumbens. The white matter tract revealed by the correlational analysis connects the anterior temporal lobe with the medial and lateral orbitofrontal cortex and also supplies the ventral striatum. The pattern of strong correlations suggests an intimate relationship between white matter structure and reward-related behavior that may also play a role in a number of pathological conditions, such as addiction and pathological gambling.
许多人类行为都受到奖励的驱动，但不同的人对奖励和惩罚的敏感程度不同。在这项研究中，我们表明，由弥散张量磁共振图像得出的各向异性分数值定义的钩束/下额枕额束的白质微观结构与短期（以内侧纹状体的 fMRI 血氧水平依赖反应来衡量奖励）和长期（以惩罚敏感度的特质衡量）对奖励的反应相关。此外，奖励处理的特质衡量也与内侧和外侧眶额皮层的伏隔核中的奖励相关功能激活相关。相关分析揭示的白质束从前颞叶连接到内侧和外侧眶额皮层，并为腹侧纹状体提供供应。强烈相关的模式表明，白质结构与奖励相关行为之间存在密切关系，这种关系也可能在一些病理状况中发挥作用，如成瘾和病理性赌博。
