Takematsu H, Tagami H
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Dermatologica. 1990;181(4):289-92. doi: 10.1159/000247825.
The complement system may play an important role in the inflammatory reaction of psoriasis. While the classical pathway of the complement has been shown to be activated in psoriasis, there have been few reports on the involvement of the alternative pathway in the inflammatory reactions in psoriasis. Complement fragments, C4d and Bb, are released at the time of the classical and alternative pathway activation, respectively. The presence of the C4d or Bb fragment, therefore, denotes a preceding complement activation through the classical and/or alternative pathway. In the present study, we have measured the levels of C4d and Bb in psoriatic scale extracts using enzyme immunoassay techniques. The scales of these dermatoses contained higher levels of C4d and Bb detectable by enzyme immunoassay than those in the stratum corneum of noninflammatory skin. These results suggest that the alternative as well as the classical pathway of complement are activated in psoriatic lesional skin.
补体系统可能在银屑病的炎症反应中起重要作用。虽然已表明补体的经典途径在银屑病中被激活，但关于替代途径参与银屑病炎症反应的报道很少。补体片段C4d和Bb分别在经典途径和替代途径激活时释放。因此，C4d或Bb片段的存在表示先前通过经典和/或替代途径的补体激活。在本研究中，我们使用酶免疫测定技术测量了银屑病鳞屑提取物中C4d和Bb的水平。这些皮肤病的鳞屑中通过酶免疫测定可检测到的C4d和Bb水平高于非炎症性皮肤角质层中的水平。这些结果表明补体的替代途径以及经典途径在银屑病皮损皮肤中被激活。
