Sluijs I, van der A D L, Beulens J W J, Spijkerman A M W, Ros M M, Grobbee D E, van der Schouw Y T
University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, the Netherlands.
Neth J Med. 2010 Aug;68(1):333-9.
The objectives of this study were to describe in detail the ascertainment and verification of prevalent and incident diabetes in the Dutch contributor to the European Prospective Investigation into Cancer and Nutrition (EPIC-NL cohort) and to examine to what extent ascertained diabetes agreed with general practitioner (GP) and pharmacy records.
In total, 40,011 adults, aged 21 to 70 years at baseline, were included. Diabetes was ascertained via self-report, linkage to registers of hospital discharge diagnoses (HDD) and a urinary glucose strip test. Ascertained diabetes cases were verified against GP or pharmacist information using mailed questionnaires.
At baseline, 795 (2.0%) diabetes cases were ascertained, and 1494 (3.7%) during a mean follow-up of ten years. The majority was ascertained via self-report only (56.7%), or self-report in combination with HDD (18.0%). After verification of ascertained diabetes cases, 1532 (66.9%) [corrected] were defined as having diabetes , 495 (21.6%) as non-diabetic individuals, and 262 (11.5%) as uncertain. Of the 1538 cases ascertained by self-report, 1350 (positive predictive value: 87.8%) were confirmed by GP or pharmacist. Cases ascertained via self-report in combination with HDD were most often confirmed (334 (positive predictive value: 96.0%)).
Two out of three ascertained diabetes cases were confirmed to have been diagnosed with diabetes by their GP or pharmacist. Diabetes cases ascertained via self-report in combination with HDD had the highest confirmation.
本研究的目的是详细描述在欧洲癌症与营养前瞻性调查荷兰参与者队列（EPIC-NL队列）中对糖尿病患病率和发病率的确定与验证情况，并考察所确定的糖尿病病例与全科医生（GP）及药房记录的相符程度。
总共纳入了40,011名基线年龄在21至70岁之间的成年人。通过自我报告、与医院出院诊断登记册（HDD）的关联以及尿糖试纸检测来确定糖尿病。使用邮寄问卷根据全科医生或药剂师的信息对所确定的糖尿病病例进行验证。
在基线时，确定了795例（2.0%）糖尿病病例，在平均十年的随访期间确定了1494例（3.7%）。大多数病例仅通过自我报告确定（56.7%），或通过自我报告与HDD相结合确定（18.0%）。在所确定的糖尿病病例经过验证后，1532例（66.9%）[校正后]被定义为患有糖尿病，495例（21.6%）为非糖尿病个体，262例（11.5%）为不确定。在通过自我报告确定的1538例病例中，1350例（阳性预测值：87.8%）得到了全科医生或药剂师的确认。通过自我报告与HDD相结合确定的病例最常得到确认（334例，阳性预测值：96.0%）。
三分之二所确定的糖尿病病例经其全科医生或药剂师确认已被诊断患有糖尿病。通过自我报告与HDD相结合确定的糖尿病病例确认率最高。
