β2 肾上腺素能受体基因多态性与汉族人群原发性高血压的相关性研究。

Associations of polymorphisms in the β2-adrenergic receptor gene with essential hypertension in Han Chinese population.

机构信息

Department of Cardiology, The First Affiliated Hospital of South China University, Hengyang 421001, China.

出版信息

Mol Biol Rep. 2012 Oct;39(10):9339-45. doi: 10.1007/s11033-012-1750-5. Epub 2012 Jul 5.

Abstract

The β2-adrenergic receptor (β2-AR) gene has been implicated in the pathogenesis of hypertension. However, the results have been conflicting. In this study, we performed a meta-analysis to assess the associations of 46A/G and 79C/G polymorphisms in β2-AR gene with hypertension risk in Han Chinese population. Published literature from PubMed, ISI Web of Science, Embase databases, CNKI, CBM and Wanfang Data were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed- or random-effects model. Eleven studies (2,058 cases and 1,459 controls) for 46A/G polymorphism and eight studies (2,219 cases and 1,495 controls) for 79C/G polymorphism were identified. The results suggested that 46A/G polymorphism G allele might increase the risk of hypertension (GG vs. AA: OR = 1.47, 95 % CI 1.20-1.82). However, no significant association was observed for 79C/G polymorphism (GG vs. CC: OR = 1.05, 95 % CI 0.61-1.79). The results indicated that 46A/G polymorphism in the β2-AR gene was associated with hypertension susceptibility in Han Chinese population.

摘要

β2-肾上腺素能受体（β2-AR）基因与高血压的发病机制有关。然而，结果一直存在争议。在这项研究中，我们进行了荟萃分析，以评估β2-AR 基因中的 46A/G 和 79C/G 多态性与汉族人群高血压风险的关联。从 PubMed、ISI Web of Science、Embase 数据库、CNKI、CBM 和万方数据中检索到已发表的文献。使用固定效应或随机效应模型计算合并优势比（OR）及其 95%置信区间（CI）。确定了 11 项研究（2058 例病例和 1459 例对照）用于 46A/G 多态性，8 项研究（2219 例病例和 1495 例对照）用于 79C/G 多态性。结果表明，46A/G 多态性 G 等位基因可能增加高血压的风险（GG 与 AA：OR=1.47，95%CI 1.20-1.82）。然而，79C/G 多态性没有观察到显著关联（GG 与 CC：OR=1.05，95%CI 0.61-1.79）。结果表明，β2-AR 基因中的 46A/G 多态性与汉族人群的高血压易感性有关。