Kancharla Venkat Pavan, Gulmi Frederick A, Agheli Aref, Degen Michael, Gohari Arash, Jiang Ming, Wang J C
Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, N.Y., USA.
Case Rep Oncol. 2010 Apr 30;3(2):125-130. doi: 10.1159/000312424.
Bladder cancer usually spreads via the lymphatic and hematogenous routes, the most common sites of metastases of urinary bladder cancers being the regional lymph nodes, liver, lung, bone, peritoneum, pleura, kidney, adrenal gland and intestines. Generalized lymph node metastasis of transitional cell cancer of the bladder is extremely rare. According to our literature search, there has been no case report of transitional cell cancer of the bladder that manifests as an extensive large lymph node metastasis involving the intraparotid, supraclavicular thoracic inlet, axillary and regional abdominal and pelvic lymph nodes without bone or visceral organs involved. Such a presentation could be mistaken as malignant lymphoma and the importance of a biopsy of the lymph nodes is emphasized. The clinical course of rapid progression of the disease and the presence of wild-type p53 with rapid response to chemotherapy and a short remission may represent a unique case, which is discussed here.
膀胱癌通常通过淋巴和血行途径转移，膀胱癌转移最常见的部位是区域淋巴结、肝脏、肺、骨、腹膜、胸膜、肾脏、肾上腺和肠道。膀胱移行细胞癌的广泛性淋巴结转移极为罕见。根据我们的文献检索，尚无膀胱移行细胞癌表现为广泛的大淋巴结转移，累及腮腺内、锁骨上胸廓入口、腋窝以及区域腹部和盆腔淋巴结而无骨骼或内脏器官受累的病例报告。这种表现可能会被误诊为恶性淋巴瘤，因此强调了淋巴结活检的重要性。疾病快速进展的临床过程以及野生型p53的存在，对化疗反应迅速且缓解期短，这可能代表了一个独特的病例，在此进行讨论。
