Gordon-Evans W J, Dunning D, Johnson A L, Knap K E
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, 1008 W Hazelwood Drive, Urbana, IL 61802, USA.
Vet Comp Orthop Traumatol. 2010;23(5):332-5. doi: 10.3415/VCOT-09-11-0121. Epub 2010 Aug 25.
During intense physical exercise, the cyclo-oxygenase-2 (COX-2) pathway is upregulated which contributes to soreness. The aim of this study was to determine if there was a clinical affect of deracoxib (COX-2 selective antagonist) on dogs engaged in intense rehabilitation following tibial plateau levelling osteotomy for cranial cruciate ligament rupture. Our hypothesis was that dogs receiving deracoxib would demonstrate less lameness, better range-of-motion (ROM), and faster muscle mass recovery than the control dogs. Thirty dogs were randomised to the treatment (deracoxib at 1-2 mg/kg once daily by mouth) or control (no treatment) group. Outcomes including gait analysis, thigh circumference, and goniometry, were measured by one investigator, who was masked to group preoperatively, and at the end of each intense rehabilitation week (3, 5, and 7 weeks postoperatively). The only difference between groups for any outcome measure at any time point was a greater preoperative stifle ROM in the group receiving deracoxib (p = 0.04). This study showed that treatment with deracoxib did not provide better outcomes when dogs were subjected to intense rehabilitation after tibial plateau levelling osteotomy. Each patient should be evaluated individually to determine if administration of deracoxib is appropriate.
在剧烈体育锻炼期间，环氧化酶-2（COX-2）途径上调，这会导致酸痛。本研究的目的是确定德拉考昔（一种COX-2选择性拮抗剂）对因颅交叉韧带断裂行胫骨平台水平截骨术后进行强化康复训练的犬是否有临床效果。我们的假设是，接受德拉考昔治疗的犬比对照犬跛行程度更轻、关节活动范围（ROM）更好且肌肉质量恢复更快。30只犬被随机分为治疗组（口服德拉考昔，剂量为1 - 2 mg/kg，每日一次）或对照组（不治疗）。包括步态分析、大腿周长和测角法在内的结果由一名研究人员测量，该研究人员在术前对分组情况不知情，且在术后每个强化康复周（术后3、5和7周）结束时进行测量。在任何时间点，两组之间任何结果测量指标的唯一差异是接受德拉考昔治疗的组术前膝关节ROM更大（p = 0.04）。本研究表明，在胫骨平台水平截骨术后进行强化康复训练的犬中，使用德拉考昔治疗并未带来更好的结果。应针对每个患者进行个体评估，以确定给予德拉考昔是否合适。
