Department of Cranio-Maxillo-Facial Surgery, University of Würzburg, Pleicherwall 2, 97070 Würzburg, Germany.
J Mater Sci Mater Med. 2010 Nov;21(11):2947-53. doi: 10.1007/s10856-010-4148-8. Epub 2010 Aug 26.
Synthetic bone replacement materials are of great interest because they offer certain advantages compared with organic bone grafts. Biodegradability and preoperative manufacturing of patient specific implants are further desirable features in various clinical situations. Both can be realised by 3D powder printing. In this study, we introduce powder-printed magnesium ammonium phosphate (struvite) structures, accompanied by a neutral setting reaction by printing farringtonite (Mg(3)(PO(4))(2)) powder with ammonium phosphate solution as binder. Suitable powders were obtained after sintering at 1100°C for 5 h following 20-40 min dry grinding in a ball mill. Depending on the post-treatment of the samples, compressive strengths were found to be in the range 2-7 MPa. Cytocompatibility was demonstrated in vitro using the human osteoblastic cell line MG63.
合成骨替代材料具有很大的吸引力，因为它们与有机骨移植物相比具有某些优势。在各种临床情况下，可生物降解性和术前制造患者特定植入物是进一步需要的特性。这两者都可以通过 3D 粉末打印来实现。在这项研究中，我们介绍了粉末打印的磷酸镁铵（鸟粪石）结构，并通过用含氨磷酸盐溶液作为粘结剂打印 farringtonite（Mg(3)(PO(4))(2)）粉末伴随中性的凝固反应。将合适的粉末在球磨机中干燥研磨 20-40 分钟后，在 1100°C 下烧结 5 小时即可获得。根据样品的后处理，抗压强度在 2-7 MPa 范围内。通过体外使用人成骨肉瘤细胞系 MG63 证明了细胞相容性。
