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美沙酮治疗 5 年后阿片类药物依赖者的当前生活质量及其决定因素。

Current quality of life and its determinants among opiate-dependent individuals five years after starting methadone treatment.

机构信息

Department of Orthopedagogics, Ghent University, H Dunantlaan 2, 9000 Ghent, Belgium.

出版信息

Qual Life Res. 2011 Feb;20(1):139-50. doi: 10.1007/s11136-010-9732-3. Epub 2010 Aug 26.

Abstract

PURPOSE

This study explores the current QoL of opiate-dependent individuals who started outpatient methadone treatment at least 5 years ago and assesses the influence of demographic, psychosocial, drug and health-related variables on individuals' QoL.

METHODS

Participants (n = 159) were interviewed about their current QoL, psychological distress and severity of drug-related problems, using the Lancashire Quality of Life Profile, the Brief Symptom Inventory and the Addiction Severity Index. Potential determinants of QoL were assessed in a multiple linear regression analysis.

RESULTS

Five years after the start of methadone treatment, opiate-dependent individuals report low QoL scores on various domains. No association was found between drug-related variables and QoL, but a significant negative impact of psychological distress was identified. Severity of psychological distress, taking medication for psychological problems and the inability to change one's living situation were associated with lower QoL. Having at least one good friend and a structured daily activity had a significant, positive impact on QoL.

CONCLUSIONS

Opiate-dependent individuals' QoL is mainly determined by their psychological well-being and a number of psychosocial variables. These findings highlight the importance of a holistic approach to treatment and support in methadone maintenance treatment, which goes beyond fixing the negative physical consequences of opiate dependence.

摘要

目的

本研究旨在探讨至少 5 年前开始门诊美沙酮治疗的阿片类药物依赖者的当前生活质量,并评估人口统计学、心理社会、药物和健康相关变量对个体生活质量的影响。

方法

采用兰开夏生活质量概况、简明症状量表和成瘾严重程度指数对 159 名参与者进行当前生活质量、心理困扰和药物相关问题严重程度的访谈。采用多元线性回归分析评估生活质量的潜在决定因素。

结果

在开始美沙酮治疗 5 年后,阿片类药物依赖者在各个领域的生活质量评分较低。药物相关变量与生活质量之间没有关联,但心理困扰的严重程度与生活质量显著负相关。心理困扰的严重程度、因心理问题而服用药物以及无法改变自己的生活状况与较低的生活质量相关。至少有一个好朋友和有规律的日常活动对生活质量有显著的积极影响。

结论

阿片类药物依赖者的生活质量主要由他们的心理健康和一些心理社会变量决定。这些发现强调了在美沙酮维持治疗中采用整体方法治疗和支持的重要性,这超越了纠正阿片类药物依赖的负面身体后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3985/3023858/f87835964a01/11136_2010_9732_Fig1_HTML.jpg

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