Ermachenko A B, Danilov Iu V
Gig Sanit. 1990 Oct(10):65-7.
Certain aspects of kidney metabolism under a complex organism exposure to mercury have been studied. Different kinds of the heavy metal effect on various chains of metabolism have been established, dependent on the concentration and duration of mercury intake, which is evidence of the many mechanisms and ways of detoxication process. Oxido-reduction enzymes activity is changed due to direct mercury exposure, as well as due to disturbances in boundness of metabolic processes in which these enzymes are involved. The peculiarity of thiolysis mercury effect is the influence of mercury on protein metabolism enzymes--glutamate dehydrogenase (GDG) and NADF-dependent GDG, which is closely related to restructuring of oxidation-reduction kidney functions.
已经研究了复杂生物体接触汞时肾脏代谢的某些方面。已经确定了不同种类的重金属对各种代谢链的影响，这取决于汞摄入的浓度和持续时间，这证明了解毒过程的多种机制和方式。氧化还原酶的活性由于直接接触汞而发生变化，也由于这些酶所参与的代谢过程的结合受到干扰而发生变化。硫解汞效应的独特之处在于汞对蛋白质代谢酶——谷氨酸脱氢酶（GDG）和NADF依赖性GDG的影响，这与肾脏氧化还原功能的重组密切相关。
