Monash Newborn, Monash Medical Centre, Monash University, 246, Clayton Road, Clayton, VIC 3168, Australia.
Indian J Pediatr. 2010 Sep;77(9):1029-31. doi: 10.1007/s12098-010-0159-1. Epub 2010 Aug 26.
Infants with preterm prolonged rupture of membranes can present with immediate onset of pulmonary insufficiency and need aggressive ventilatory support. Dry lung syndrome remains an under-recognised clinical entity and very few cases are reported in the literature, though a working definition has been previously proposed. The proposed underlying etiopathogenesis for this is functional hypoplasia of the lung where higher than usual ventilatory pressure for initial 1-2 days can improve oxygenation. This study presents two cases which had similar antenatal and immediate postnatal course, but had diametrically opposite outcomes. Strategies to optimise outcomes in the setting of early premature rupture of the membranes should include antenatal assessment of mothers with monitoring of the liquor volume as well as the strength of foetal breathing movements, in-utero transfer with delivery in perinatal centres and attendance by neonatal staff of appropriate experience.
患有胎膜早破延长的早产儿可能会立即出现肺功能不全，并需要积极的通气支持。干燥肺综合征仍然是一种未被充分认识的临床实体，尽管以前已经提出了一个工作定义，但在文献中很少有病例报道。这种综合征的潜在发病机制是肺功能发育不全，最初 1-2 天使用高于常规的通气压力可以改善氧合。本研究介绍了两例具有相似的产前和即刻产后病程的病例，但结果却截然相反。在早期胎膜早破的情况下，优化治疗效果的策略应包括对母亲进行产前评估，监测羊水容量和胎儿呼吸运动的强度，进行宫内转运，并在围产期中心分娩，由具有适当经验的新生儿科工作人员进行监护。
