Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC.
J Surg Oncol. 2010 Sep 1;102(3):264-70. doi: 10.1002/jso.21623.
The purpose of this study was to investigate genetic impact of monocyte chemoattractant protein-1 (MCP-1) and its receptor chemokine receptor-2 (CCR2) gene polymorphisms on the susceptibility and clinicopathological characteristics of hepatocellular carcinoma (HCC).
A total of 446 subjects, including 344 healthy controls and 102 patients with HCC, were recruited in this study and subjected to PCR-RFLP to estimate the impact of these two polymorphic variants on HCC.
No relationship between MCP-1 -2518G/A gene polymorphism and HCC risk was found among our recruited HCC patients and healthy controls. However, there was a significantly increased risk (AOR = 1.91; 95% CI = 1.11-3.29) of having HCC among subjects with GA heterozygotes of CCR2 V64I after adjusting for other confoundings. There was no synergistic effect between gene polymorphism and environmental risk factors, including tobacco and alcohol consumptions, as well as clinicopathological parameters of HCC for MCP-1 -2518G/A and CCR2 V64I genes, respectively.
CCR2-64I gene polymorphism is an important factor for the susceptibility of HCC but it might not influence the clinical pathological progression of HCC, and the contribution of CCR2-64I gene polymorphism on the susceptibility of HCC could be not through the affection of liver injury-related clinical pathological characteristics.
本研究旨在探讨单核细胞趋化蛋白-1（MCP-1）及其受体趋化因子受体-2（CCR2）基因多态性对肝细胞癌（HCC）易感性和临床病理特征的遗传影响。
本研究共纳入 446 例受试者，包括 344 例健康对照者和 102 例 HCC 患者，采用 PCR-RFLP 法估计这两种多态性变异对 HCC 的影响。
在本研究纳入的 HCC 患者和健康对照者中，MCP-1-2518G/A 基因多态性与 HCC 风险之间无相关性。然而，在校正其他混杂因素后，CCR2 V64I 基因 GA 杂合子的受试者发生 HCC 的风险显著增加（OR=1.91；95%CI=1.11-3.29）。MCP-1-2518G/A 和 CCR2 V64I 基因的基因多态性与环境危险因素（包括吸烟和饮酒）以及 HCC 的临床病理参数之间不存在协同作用。
CCR2-64I 基因多态性是 HCC 易感性的重要因素，但可能不会影响 HCC 的临床病理进展，CCR2-64I 基因多态性对 HCC 易感性的贡献可能不是通过影响与肝损伤相关的临床病理特征。
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