口腔鳞状细胞癌中 MCP-1 和 CCR2 基因变异。
MCP-1 and CCR2 gene variants in oral squamous cell carcinoma.
机构信息
Faculty of Dentistry, Department of Oral Surgery and Medicine, Istanbul University, Turkey.
出版信息
Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
AIM
We aimed to investigate a possible association of the MCP-1 and CCR2 polymorphisms with the risk of developing oral squamous cell carcinoma (OSCC).
METHODS
MCP-1 A2518G and CCR2 V64I gene polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism, in 129 patients with OSCC and 140 healthy control subjects.
RESULTS
Individuals who had G allele and GG genotype of MCP-1, and 64I allele and wt/64I genotype of CCR2 had increased risk for OSCC (P<0.05.) In contrast, individuals with CCR2 wt/wt genotype seem to be protected from OSCC (P < 0.01). Haplotype analysis revealed that MCP-1G: CCR2 64I haplotype frequencies were significantly higher in patients than those of controls (P = 0.001).
CONCLUSIONS
We can suggest that the G allele of MCP-1 and 64I allele of CCR2 may be risk factors for OSCC.
目的
本研究旨在探讨趋化因子（单核细胞趋化蛋白-1，MCP-1）和趋化因子受体 2（CCR2）的单核苷酸多态性（SNP）与口腔鳞状细胞癌（OSCC）发病风险之间的可能关联。
方法
采用聚合酶链反应和限制性片段长度多态性方法，对 129 例 OSCC 患者和 140 例健康对照者的 MCP-1 A2518G 和 CCR2 V64I 基因多态性进行检测。
结果
MCP-1 的 G 等位基因和 GG 基因型，以及 CCR2 的 64I 等位基因和 wt/64I 基因型的个体，患 OSCC 的风险增加（P<0.05）。相反，CCR2 的 wt/wt 基因型的个体似乎对 OSCC 有保护作用（P<0.01）。单体型分析显示，与对照组相比，MCP-1G：CCR2 64I 单体型频率在患者中显著升高（P=0.001）。
结论
我们可以推测，MCP-1 的 G 等位基因和 CCR2 的 64I 等位基因可能是 OSCC 的危险因素。
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