Cucinotta D, Conti Nibali S, Arrigo T, Di Benedetto A, Magazzù G, Di Cesare E, Costantino A, Pezzino V, De Luca F
Institute of Pediatrics, University of Messina, Italy.
Horm Res. 1990;34(1):33-8. doi: 10.1159/000181792.
Beta cell function, peripheral sensitivity to insulin and specific pancreatic autoimmunity were studied in 30 youngsters with cystic fibrosis (CF) accurately selected in order to fulfill the criteria for normal glucose tolerance. With respect to weight-matched controls, patients with CF exhibited a significantly lower glucose tolerance and a globally preserved, although delayed, insulin response to oral glucose tolerance test, while first-phase insulin secretion after i.v. glucose was blunted. Peripheral sensitivity to insulin, assessed in vivo by both the euglycemic clamp technique and the number of insulin receptors, directly measured in circulating monocytes, was superimposable in patients and controls. Serum islet-cell antibodies were not found in any of the patients. In conclusion, disorders of beta cell function may be observed in CF patients even when glucose tolerance is within the normal range. Such abnormalities are not associated with changes in peripheral sensitivity to insulin and do not seem to depend on specific autoimmune events.
对30名准确挑选出的符合正常糖耐量标准的囊性纤维化（CF）青少年进行了β细胞功能、外周胰岛素敏感性和特异性胰腺自身免疫性的研究。与体重匹配的对照组相比，CF患者的糖耐量显著降低，口服葡萄糖耐量试验时胰岛素反应虽延迟但总体保持，而静脉注射葡萄糖后的第一相胰岛素分泌减弱。通过正常血糖钳夹技术和直接在循环单核细胞中测量的胰岛素受体数量在体内评估的外周胰岛素敏感性，在患者和对照组中是重叠的。所有患者均未检测到血清胰岛细胞抗体。总之，即使CF患者的糖耐量在正常范围内，也可能观察到β细胞功能障碍。这些异常与外周胰岛素敏感性的变化无关，似乎也不依赖于特定的自身免疫事件。
