Temcharoen P, Anukarahanonta T, Bhamarapravati N
Cancer Res. 1978 Jul;38(7):2185-90.
The influence of dietary protein content and dietary vitamin B12 supplement on the hepatotoxicity and carcinogenicity of aflatoxin in rat liver was studied. In animals fed a low-protein diet, aflatoxin induced extensive toxic and carcinogenic effects. Cirrhosis was significantly prevented to a certain level by vitamin B12 administration, but the incidence of cholangiofibrosis and hyperplastic nodules was unchanged. No toxic effect was observed in animals receiving high-protein diet with no vitamin B12 supplement in this study (33 weeks). Only one rat bearing a hepatoma was observed in this group. However, hepatoma and hyperplastic nodules were found in the group receiving high-protein diet plus vitamin B12. Cholangiofibrosis and cirrhosis were not observed in the high-protein group regardless of vitamin B12 administration.
研究了膳食蛋白质含量和膳食维生素B12补充剂对大鼠肝脏中黄曲霉毒素肝毒性和致癌性的影响。在喂食低蛋白饮食的动物中，黄曲霉毒素会引发广泛的毒性和致癌作用。通过给予维生素B12，肝硬化在一定程度上得到了显著预防，但胆管纤维化和增生性结节的发生率没有变化。在本研究（33周）中，接受高蛋白饮食且未补充维生素B12的动物未观察到毒性作用。该组仅观察到一只患有肝癌的大鼠。然而，在接受高蛋白饮食加维生素B12的组中发现了肝癌和增生性结节。无论是否给予维生素B12，高蛋白组均未观察到胆管纤维化和肝硬化。
