Liapina L A, Pastorova V E, Kudriashov B A
Izv Akad Nauk SSSR Biol. 1990 Nov-Dec(6):881-8.
A rat platelet factor has a high antiheparin activity. It also decreases nonenzymatic fibrinolytic activity of normal rat plasma and antithrombin III-heparin complex. The platelet factor 4 formed inactive complexes with heparin in molar ratios of 1:1 and 2:1. Intravenous injection of the platelet factor 4 before injection of albino rats with tissue thromboplastin prevented the reaction of anticoagulation system inactivated the synthesis of endogenous thrombin. This effect is accompanied by high hypercoagulation and depression of nonenzymatic fibrinolysis in blood.
一种大鼠血小板因子具有较高的抗肝素活性。它还会降低正常大鼠血浆及抗凝血酶III-肝素复合物的非酶促纤维蛋白溶解活性。血小板因子4与肝素以1:1和2:1的摩尔比形成无活性复合物。在给白化大鼠注射组织凝血活酶之前静脉注射血小板因子4，可防止抗凝系统反应使内源性凝血酶的合成失活。这种效应伴随着血液中高度的高凝状态和非酶促纤维蛋白溶解的抑制。
