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[静脉注射肝素-抗凝血酶III复合物后动物血浆的抗凝和非酶促纤维蛋白溶解活性]

[Anticoagulant and nonenzymatic fibrinolytic activity of plasma in animals after intravenous injection of a heparin-antithrombin III complex].

作者信息

Kudriashov B A, Pastorova V E, Liapina L A

出版信息

Biull Eksp Biol Med. 1985 Jan;99(1):62-4.

PMID:3967074
Abstract

The heparin-antithrombin III complex with a weight ratio 1:3 had a powerful anticoagulant and non-enzymatic fibrinolytic activity in vitro. Seven and 30 min after intravenous injection of the complex the animal blood plasma showed a considerable prolongation of the thrombin time and an increase in non-enzymatic fibrinolytic activity. The effect of heparin injected in a dose equivalent to its content in the complex on the parameters under study was appreciably less and disappeared by the 30th minute of the observation period.

摘要

重量比为1:3的肝素-抗凝血酶III复合物在体外具有强大的抗凝和非酶促纤溶活性。静脉注射该复合物7分钟和30分钟后，动物血浆的凝血酶时间显著延长，非酶促纤溶活性增加。以与复合物中肝素含量相当的剂量注射肝素，对所研究参数的影响明显较小，且在观察期第30分钟时消失。

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1
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