Shimizu N, Sawada T, Inoue Y, Shimizu T, Murakami A, Hamazoe R, Maeta M, Koga S
1st Department of Surgery, Tottori University School of Medicine.
Nihon Gan Chiryo Gakkai Shi. 1990 Dec 20;25(12):2752-7.
Recently, high aged patients with malignancies have increased in number. When cancer chemotherapy is applied for the high aged patients, kinds or doses of anti-cancer drugs must be more carefully selected or decided than for younger patients, because it is said that the side effects of anti-cancer drugs would easily induce irreversible organ disorders and death in high aged patients. The effects of cancer chemotherapy were compared between high aged patients (over 75 years) and younger patients (5 decade years) with special reference to side effects. The patients underwent cancer chemotherapy were 79.7% of high aged patients and 93.6% of younger. The reasons why cancer chemotherapy was not carried out were high age (5.6% of high aged patients), poor general conditions (7.0% in high aged, 2.3% in younger) and post operative complications (7.0% in high aged, 3.2% in younger). The proportion of patients suffered side effects was almost same in both groups. Dead cases caused by side effects of anti-cancer drugs were 5 in high aged patients (4.4%) and 7 in younger (3.4%). The reason why the proportion of side effects in both groups was not different was that the doses of anti-cancer drugs given for high aged patients were reduced to 80-90% of those for younger patients.
近年来，老年恶性肿瘤患者数量有所增加。对老年患者进行癌症化疗时，与年轻患者相比，必须更谨慎地选择抗癌药物的种类或剂量，因为据说抗癌药物的副作用在老年患者中更容易引发不可逆的器官功能障碍和死亡。特别参照副作用情况，对老年患者（75岁以上）和年轻患者（50岁左右）的癌症化疗效果进行了比较。接受癌症化疗的患者中，老年患者占79.7%，年轻患者占93.6%。未进行癌症化疗的原因包括高龄（老年患者中的5.6%）、全身状况差（老年患者中的7.0%，年轻患者中的2.3%）以及术后并发症（老年患者中的7.0%，年轻患者中的3.2%）。两组中出现副作用的患者比例几乎相同。因抗癌药物副作用导致死亡的病例，老年患者有5例（4.4%），年轻患者有7例（3.4%）。两组副作用比例没有差异的原因是，给予老年患者的抗癌药物剂量减至年轻患者的80 - 90%。
