Akaike M, Inazu M, Ohno H, Takayama K, Omosu M, Kobayashi T
Pharma Research Laboratories, Hoechst Japan Limited, Saitama.
J Toxicol Sci. 1990 Nov;15 Suppl 3:109-27. doi: 10.2131/jts.15.supplementiii_109.
Cefpirome sulfate (CPR) was administered subcutaneously at 200, 500, and 1000 mg/kg/day to male rats for 5 weeks from 6 through 40 days of age and examinations were made to determine whether the antibiotic caused any detrimental effects on male sexual development when administered to juvenile rats. Cefotetan (CTT) was given at 1000 mg/kg/day as a positive control. Incrustation occurred at the injection site during administration in all treated groups. The CPR groups had no compound related changes in fertility, spermatozoa, and reproductive organs, while the CTT group showed decreased testicular weight, abnormal fertility and spermatozoa, and atrophied germinal epithelium of seminiferous tubules, atrophied epididymis, and decreased number of spermatozoa. From the results of this investigation, it may be concluded that CPR had no effects on male sexual development when administered to juvenile rats.
从6日龄至40日龄，将硫酸头孢匹罗（CPR）以200、500和1000mg/kg/天的剂量皮下注射给雄性大鼠，持续5周，以确定该抗生素在给幼年大鼠使用时是否会对雄性性发育产生任何有害影响。以1000mg/kg/天的剂量给予头孢替坦（CTT）作为阳性对照。在给药期间，所有治疗组的注射部位均出现结痂。CPR组在生育力、精子和生殖器官方面没有与化合物相关的变化，而CTT组则表现出睾丸重量减轻、生育力和精子异常、生精小管生精上皮萎缩、附睾萎缩以及精子数量减少。根据本研究结果，可以得出结论，CPR在给幼年大鼠使用时对雄性性发育没有影响。
