Sugiyama O, Tanaka K, Toya M, Igarashi S, Watanabe K, Watanabe S, Tsuji K, Kumagai Y
Toxicology Research Laboratories, Chugai Pharmaceutical Co., Ltd., Nagano, Japan.
J Toxicol Sci. 1990 Nov;15 Suppl 3:53-64. doi: 10.2131/jts.15.supplementiii_53.
A fertility study was performed in rats by intraperitoneal administration of cefpirome sulfate (CPR) at dose levels of 0 (control), 200, 400 and 800 mg/kg/day. Male rats were treated for 60 days before mating and during the mating period. Female rats were administrated the substance from 14 days before mating to day 7 of pregnancy. The females were sacrificed on day 21 of pregnancy for examination of their fetuses. No animal died during the administration period. Loose feces were observed in both male and female animals in the 400 and 800 mg/kg/day groups. Body weight gain was suppressed in both male and female animals in the 800 mg/kg/day group and in male animals in the 400 mg/kg/day group. There were no significant differences in food and water intakes between treated and control groups. Autopsy revealed the enlargement of the caecum in males in the 200, 400 and 800 mg/kg/day groups. The kidney and adrenal weights were significantly increased in males in the 200, 400 and 800 mg/kg/day groups. Fertility and reproductive ability in both sexes, and estrus cycles in female rats were not affected by administration of CPR. There were no lethal effect and growth-inhibiting or teratogenic effects on the embryos and the fetuses. The results suggest that the non-effective dose level of CPR was lower than 200 and 200 mg/kg/day for general toxicity in male and female parent animals respectively, 800 mg/kg/day for reproductive ability in parent animals and in embryos and fetuses.
通过腹腔注射剂量为0（对照）、200、400和800mg/kg/天的硫酸头孢匹罗（CPR）对大鼠进行了一项生育力研究。雄性大鼠在交配前和交配期间接受60天的治疗。雌性大鼠在交配前14天至怀孕第7天给予该物质。在怀孕第21天处死雌性大鼠以检查其胎儿。给药期间无动物死亡。在400和800mg/kg/天组的雄性和雌性动物中均观察到稀便。800mg/kg/天组的雄性和雌性动物以及400mg/kg/天组的雄性动物体重增加受到抑制。治疗组和对照组之间的食物和水摄入量没有显著差异。尸检显示200、400和800mg/kg/天组雄性大鼠的盲肠增大。200、400和800mg/kg/天组雄性大鼠的肾脏和肾上腺重量显著增加。CPR给药对两性的生育力和生殖能力以及雌性大鼠的发情周期没有影响。对胚胎和胎儿没有致死作用、生长抑制或致畸作用。结果表明，CPR对雄性和雌性亲代动物一般毒性的无效剂量水平分别低于200和200mg/kg/天，对亲代动物以及胚胎和胎儿生殖能力的无效剂量水平为800mg/kg/天。
