Diodati G, Bonetti P, Plebani M, Giacomini A, Rugge M, Realdi G, Burlina A
Istituto di Medicina Clinica, Università degli Studi di Padova.
Ric Clin Lab. 1990 Oct-Dec;20(4):253-9. doi: 10.1007/BF02900710.
Sera from 64 patients with HBsAg-negative chronic liver disease with or without cirrhosis were investigated for aminoterminal peptide of type III procollagen (sP-III-P) as a suitable marker of hepatic fibrosis; 244 healthy control subjects were included in the study. A close correlation (p less than 0.01) between sP-III-P levels and histological activity was observed; on the contrary, no correlation was found between the same serum marker of liver fibroplasia and biochemical activity or clinical severity of the disease. We conclude that sP-III-P as a suitable marker of liver overload of collagen fibers is strongly correlated with the histological activity of the disease. Local immune reactions produce soluble substances that might stimulate fibroblastic activity. The test has a significant sensitivity and a very high specificity as a marker of chronic liver disease with histological activity.
对64例患有或未患有肝硬化的HBsAg阴性慢性肝病患者的血清进行了研究，以检测III型前胶原氨基末端肽（sP-III-P）作为肝纤维化的合适标志物；244名健康对照者纳入研究。观察到sP-III-P水平与组织学活性之间存在密切相关性（p小于0.01）；相反，在肝脏纤维增生的同一血清标志物与疾病的生化活性或临床严重程度之间未发现相关性。我们得出结论，sP-III-P作为胶原纤维肝超负荷的合适标志物与疾病的组织学活性密切相关。局部免疫反应产生可能刺激成纤维细胞活性的可溶性物质。作为具有组织学活性的慢性肝病标志物，该检测具有显著的敏感性和非常高的特异性。
