Karlsson M G, Eriksson U J, Swenne I
Department of Medical Cell Biology, Uppsala University, Sweden.
Ups J Med Sci. 1990;95(2):147-55. doi: 10.3109/03009739009178583.
Fetal and neonatal hypoadrenalism was induced by treating rat mothers with metyrapone from day 12 of pregnancy to day 7 postnatally. Hypoadrenalism in the neonates was indicated by a slight reduction in body weight, adrenal hyperplasia and a tendency towards reduced adrenal corticosterone concentration. An intraperitoneal glucose tolerance test on the 7-day old neonates did not show any disturbancies of glucose disposal or insulin secretory response to glucose. The data suggest that adrenal corticosteroids are not essential for the perinatal development of the B-cell secretory response to glucose.
从妊娠第12天至产后第7天，用甲吡酮处理大鼠母亲，诱导胎儿和新生儿肾上腺功能减退。新生儿肾上腺功能减退表现为体重略有减轻、肾上腺增生以及肾上腺皮质酮浓度有降低趋势。对7日龄新生儿进行腹腔内葡萄糖耐量试验，未显示葡萄糖代谢或胰岛素对葡萄糖分泌反应有任何紊乱。数据表明，肾上腺皮质类固醇对于围产期B细胞对葡萄糖的分泌反应发育并非必不可少。
