胎儿和新生大鼠的甲状腺功能减退不会损害对葡萄糖的胰岛素分泌反应。

Hypothyroidism in the fetal and neonatal rat does not impair the insulin secretory response to glucose.

作者信息

Swenne I

出版信息

Life Sci. 1983 Nov 28;33(22):2207-11. doi: 10.1016/0024-3205(83)90292-8.

Abstract

Fetal and neonatal hypothyroidism was induced by treating pregnant rats with propylthiouracil (PTU) in the drinking water from day 12 of gestation to day 7 postnatally. The serum levels of thyroxine and triiodothyronine were lowered in both mother and offspring and the neonates showed a 20% reduction in weight gain. An i.p. glucose tolerance test on the 7-day old neonates revealed no major disturbances in glucose tolerance or insulin response. The data suggest that thyroid hormones are not essential for the neonatal development of the B-cell secretory response to glucose.

摘要

从妊娠第12天到产后第7天，通过在饮用水中给怀孕大鼠注射丙硫氧嘧啶（PTU）来诱导胎儿和新生儿甲状腺功能减退。母亲和后代的血清甲状腺素和三碘甲状腺原氨酸水平均降低，新生儿体重增加减少了20%。对7日龄新生儿进行的腹腔内葡萄糖耐量试验显示，葡萄糖耐量或胰岛素反应没有重大干扰。数据表明，甲状腺激素对于新生儿B细胞对葡萄糖的分泌反应的发育不是必需的。