Swenne I
Life Sci. 1983 Nov 28;33(22):2207-11. doi: 10.1016/0024-3205(83)90292-8.
Fetal and neonatal hypothyroidism was induced by treating pregnant rats with propylthiouracil (PTU) in the drinking water from day 12 of gestation to day 7 postnatally. The serum levels of thyroxine and triiodothyronine were lowered in both mother and offspring and the neonates showed a 20% reduction in weight gain. An i.p. glucose tolerance test on the 7-day old neonates revealed no major disturbances in glucose tolerance or insulin response. The data suggest that thyroid hormones are not essential for the neonatal development of the B-cell secretory response to glucose.
从妊娠第12天到产后第7天，通过在饮用水中给怀孕大鼠注射丙硫氧嘧啶（PTU）来诱导胎儿和新生儿甲状腺功能减退。母亲和后代的血清甲状腺素和三碘甲状腺原氨酸水平均降低，新生儿体重增加减少了20%。对7日龄新生儿进行的腹腔内葡萄糖耐量试验显示，葡萄糖耐量或胰岛素反应没有重大干扰。数据表明，甲状腺激素对于新生儿B细胞对葡萄糖的分泌反应的发育不是必需的。
