文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Barbieri L, Battelli M G, Stirpe F

Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.

Xenobiotica. 1990 Dec;20(12):1331-41. doi: 10.3109/00498259009046631.

The blood clearance, organ distribution and tissue concentration of several native, homopolymerized, and IgG-conjugated 125I-labelled ribosome-inactivating proteins (RIPs) were determined in mice. 2. Native RIPs were cleared rapidly from blood, with half-lives of 4-8 min, and were concentrated mainly in the kidneys. 3. After conjugation to IgG the three RIPs studied showed increased blood half-lives and decreased concentrations in the kidneys. 4. The two homopolymers studied had blood half-lives and kidney concentrations intermediate to those of free and conjugated RIPs. 5. These results indicate that after IgG-conjugation the increased half-lives of the RIPs studied were at least in part due to the larger molecular size of the conjugates and to their lower renal excretion.

在小鼠体内测定了几种天然、同聚化以及与IgG偶联的¹²⁵I标记核糖体失活蛋白（RIPs）的血液清除率、器官分布和组织浓度。2. 天然RIPs从血液中快速清除，半衰期为4 - 8分钟，主要集中在肾脏。3. 与IgG偶联后，所研究的三种RIPs血液半衰期延长，在肾脏中的浓度降低。4. 所研究的两种同聚物的血液半衰期和肾脏浓度介于游离和偶联RIPs之间。5. 这些结果表明，在所研究的RIPs与IgG偶联后，其半衰期延长至少部分归因于偶联物更大的分子大小及其较低的肾脏排泄率。

Barbieri L, Battelli M G, Stirpe F

Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.

Xenobiotica. 1990 Dec;20(12):1331-41. doi: 10.3109/00498259009046631.

The blood clearance, organ distribution and tissue concentration of several native, homopolymerized, and IgG-conjugated 125I-labelled ribosome-inactivating proteins (RIPs) were determined in mice. 2. Native RIPs were cleared rapidly from blood, with half-lives of 4-8 min, and were concentrated mainly in the kidneys. 3. After conjugation to IgG the three RIPs studied showed increased blood half-lives and decreased concentrations in the kidneys. 4. The two homopolymers studied had blood half-lives and kidney concentrations intermediate to those of free and conjugated RIPs. 5. These results indicate that after IgG-conjugation the increased half-lives of the RIPs studied were at least in part due to the larger molecular size of the conjugates and to their lower renal excretion.

在小鼠体内测定了几种天然、同聚化以及与IgG偶联的¹²⁵I标记核糖体失活蛋白（RIPs）的血液清除率、器官分布和组织浓度。2. 天然RIPs从血液中快速清除，半衰期为4 - 8分钟，主要集中在肾脏。3. 与IgG偶联后，所研究的三种RIPs血液半衰期延长，在肾脏中的浓度降低。4. 所研究的两种同聚物的血液半衰期和肾脏浓度介于游离和偶联RIPs之间。5. 这些结果表明，在所研究的RIPs与IgG偶联后，其半衰期延长至少部分归因于偶联物更大的分子大小及其较低的肾脏排泄率。