Battelli M G, Barbieri L, Stirpe F
Dipartimento di Patologia Sperimentale, Università di Bologna, Italy.
APMIS. 1990 Jul;98(7):585-93. doi: 10.1111/j.1699-0463.1990.tb04975.x.
The toxicity of, and the lesions brought about by, several ribosome-inactivating proteins (bryodin, gelonin, momordin, pokeweed antiviral protein from seeds, saporin 6, trichokirin and momorcochin-S), either native, or conjugated to bovine IgG, or polymerized, were studied in the mouse. Severe necrotic liver damage was the main lesion present in animals receiving lethal doses of the proteins. The toxicity of ribosome-inactivating proteins increased after conjugation to IgG or homopolymerization. The toxicity of conjugates to mouse was not predictable from the inhibitory activity on cell-free protein synthesis.
研究了几种核糖体失活蛋白（苔藓抑素、去糖链蛋白、苦瓜素、种子商陆抗病毒蛋白、皂草素6、天花粉蛋白和苦瓜核糖体失活蛋白-S）的毒性以及它们所引起的损伤，这些蛋白包括天然形式、与牛IgG偶联的形式或聚合形式，研究对象为小鼠。严重的坏死性肝损伤是接受致死剂量蛋白的动物体内出现的主要损伤。核糖体失活蛋白在与IgG偶联或均聚后毒性增加。偶联物对小鼠的毒性无法根据其对无细胞蛋白质合成的抑制活性来预测。
