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[终末期及复苏后状态下红细胞系的典型变化]

[Typical changes in the erythron in terminal and post-resuscitation states].

作者信息

Red'kin Iu V, Lobov V V, Miroshnik O A, Sokolova T F

出版信息

Anesteziol Reanimatol. 1990 Nov-Dec(6):36-40.

PMID:2075929
Abstract

Morphological and biochemical indexes of peripheral erythron compartment have been analysed 1, 3, 7 and 14 days after severe mechanical traumas of various locations in human patients, after 5- and 10-min clinical death in dogs and after rotatory polytrauma in rats. It has been shown that rehabilitation period along with usual anemization is characterized by enhanced penetration of newly formed erythrocytes (hyperchromic, fetal, lipoperoxidation-resistant forms) into the circulation. In pathologies with predominant damage of the central nervous system regenerative response of the bone marrow is less marked and normalization of hematologic parameters is less prompt. As erythron changes always take place in terminal and postresuscitation conditions, irrespective of the etiology and species, they are regarded as a typical pathological process.

摘要

对人类患者不同部位严重机械创伤后1天、3天、7天和14天,犬只经历5分钟和10分钟临床死亡后,以及大鼠旋转性多发伤后外周红细胞系统的形态学和生化指标进行了分析。结果表明,康复期除了常见的贫血外,其特征还在于新形成的红细胞(高色素性、胎儿型、抗脂质过氧化形式)进入循环的渗透率增加。在以中枢神经系统为主的损伤性病变中,骨髓的再生反应不太明显,血液学参数的正常化也不太迅速。由于红细胞系统的变化总是在终末期和复苏后条件下发生,无论病因和物种如何,它们都被视为一种典型的病理过程。

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