Zarzhetskiĭ Iu V, Mutuskina E A, Avrushchenko M Sh, Volkov A V, Gurevich A M
Anesteziol Reanimatol. 1994 Mar-Apr(2):56-9.
Rats recovered after a 10-min circulation arrest, were examined in the early postresuscitation period (within 10-12 days after resuscitation) in an open field (OF) test and during elaboration and reproduction of passive avoidance conditioned reflex (PACR); morphometric analysis of sensorimotor brain cortex was performed on days 4, 7, 14, and 30 after resuscitation. It has been shown that directly after compensation of external neurological deficit which took place in the majority of animals within 3 days the process of adaptation to new situation (OF test) in resuscitated rats, unlike the intact ones, was associated with high motor activity and not with the elaboration of stable correlations between various behavioral acts. At the same time disorders in learning and memory have been observed in PACR test. Morphometric studies have revealed changes in neuroglial relations by day 14 and considerable dystrophic neuronal changes by month 1 after resuscitation. All these disturbances took place with the overall density of neuron population preserved.
在经历10分钟循环骤停后复苏的大鼠，于复苏后早期（复苏后10 - 12天内）在旷场试验以及被动回避条件反射的建立和再现过程中接受检查；在复苏后的第4天、第7天、第14天和第30天对感觉运动脑皮质进行形态计量分析。结果显示，在大多数动物于3天内出现的外部神经功能缺损得到代偿后，复苏大鼠与未经历复苏的大鼠不同，在适应新环境（旷场试验）的过程中，其特征是运动活性高，而非各种行为之间建立稳定的关联。与此同时，在被动回避条件反射试验中观察到学习和记忆障碍。形态计量学研究显示，复苏后第14天神经胶质关系发生变化，复苏后1个月神经元出现明显的营养不良性变化。所有这些紊乱均在神经元总体密度保持不变的情况下发生。
