Dash N K, Azam M, Gupta G, Baquer N Z
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Biochem Int. 1990 Nov;22(3):475-82.
The effect of chronic administration of propranolol on the rat brain and heart acetylcholinesterase was studied by administering propranolol (5mg/kg body weight) for 14 days. This treatment was found to substantially inhibit the enzyme activity. Levels of 5-hydroxytryptamine were measured in the brain and heart; in brain the levels of 5-hydroxytryptamine increased with propranolol administration, while in the heart there was no change. Effect of different concentrations of propranolol on acetylcholinesterase activity was also studied in vitro and a decreased activity of the enzyme was found in brain and heart homogenates. The significance of these results is discussed in terms of the therapeautic effects of the drug in the control of hypertension.
通过给予大鼠普萘洛尔（5毫克/千克体重）14天，研究了长期服用普萘洛尔对大鼠脑和心脏乙酰胆碱酯酶的影响。发现这种处理可显著抑制酶活性。测定了脑和心脏中5-羟色胺的水平；在脑中，5-羟色胺水平随普萘洛尔给药而升高，而在心脏中则无变化。还在体外研究了不同浓度普萘洛尔对乙酰胆碱酯酶活性的影响，发现脑和心脏匀浆中该酶的活性降低。根据该药物在控制高血压方面的治疗效果讨论了这些结果的意义。
