普萘洛尔给药对家兔脑电图的影响。

The effect of propranolol-administration on the electroencephalogram in the rabbit.

作者信息

Czarnecka E, Ciborska-Jakubowska H, Gawlik L, Mazur M

出版信息

Acta Physiol Pol. 1977 Jan-Feb;28(1):45-50.

Abstract

The effect of propranolol-administration on the electroencephalogram in the rabbit. Acta Physiol. Pol., 1977, 28 (1): 45-50. The influence of propranolol on EEG of the rabbits, with electrodes chronically implanted into different brain structures, was studied. Propranolol in the doses of 1, 2 and 3 mg/kg was injected intravenously. The bioelectrical brain activity of the rabbits was measured several times after the drug injection. In the next period of experiments propranolol (2 mg/kg i.v.) was administered every day for 10 days. Moreover the influence of the same doses of this drug on ECG and arterial pressure was studied. It was found that propranolol-administration changes the bioelectrical activity of the brain. Such phenomenon as, voltage increase, irregular and slower rhythm, an increase in slow activity and spikes, fast activity was perceived. The changes in EEG were particularly well pronounced in subcortical structures. The described effects of propranolol do not depend on the influence of this drug on the circulatory system.

摘要

普萘洛尔给药对兔脑电图的影响。《波兰生理学报》，1977年，28(1):45 - 50。研究了普萘洛尔对长期在不同脑结构植入电极的兔脑电图的影响。静脉注射剂量为1、2和3毫克/千克的普萘洛尔。在药物注射后多次测量兔的脑生物电活动。在接下来的实验阶段，每天静脉注射普萘洛尔(2毫克/千克)，持续10天。此外，还研究了相同剂量的该药物对心电图和动脉血压的影响。发现普萘洛尔给药会改变脑的生物电活动。观察到电压升高、节律不规则且减慢、慢波活动和棘波增加、快波活动等现象。脑电图的变化在皮层下结构中尤为明显。普萘洛尔的上述作用不依赖于该药物对循环系统的影响。