促肾上腺皮质激素4-10对缺乏血管加压素的大鼠（布拉特洛伯罗品系）被动回避行为的影响。

Effect of ACTH 4-10 on passive avoidance of rats lacking vasopressin (Brattleboro strain).

作者信息

Bailey W H, Weiss J M

出版信息

Horm Behav. 1978 Feb;10(1):22-9. doi: 10.1016/0018-506x(78)90021-1.

PMID:207631

Abstract

The hypothesis that the effects of ACTH 4-10 on avoidance are mediated via the release of endogenous vasopressin was investigated. To test this hypothesis, we observed the effect of ACTH 4-10 on the passive avoidance of Brattleboro rats with diabetes insipidus resulting from a total genetic deficiency of vasopressin (DI) and Brattleboro rats without diabetes insipidus (HE). Normal Long-Evans rats (LE) were also included for comparison purposes. The results did not support the hypothesis. ACTH 4-10 did influence the passive avoidance of DI rats; this should not have occurred if the release of endogenous vasopressin is necessary for ACTH 4-10 to influence avoidance.

摘要

研究了促肾上腺皮质激素4 - 10（ACTH 4 - 10）对回避行为的影响是通过内源性血管加压素的释放介导的这一假说。为了验证这一假说，我们观察了ACTH 4 - 10对完全缺乏血管加压素导致尿崩症的Brattleboro大鼠（DI）和无尿崩症的Brattleboro大鼠（HE）被动回避行为的影响。为作比较，还纳入了正常的Long - Evans大鼠（LE）。结果不支持该假说。ACTH 4 - 10确实影响了DI大鼠的被动回避行为；如果ACTH 4 - 10影响回避行为需要内源性血管加压素的释放，那么这种情况就不应该发生。