Laulin J P, Ezzarani E A, Brudieux R
Horm Metab Res. 1984 May;16(5):254-7. doi: 10.1055/s-2007-1014758.
Plasma concentration, metabolic clearance rate and in vitro adrenal production of aldosterone were measured in Brattleboro male rats with inherited diabetes insipidus (DI) and in Long-Evans male rats (LE) as controls. Plasma concentration of aldosterone was significantly lower (-48.3%) in DI rats than in LE rats. Metabolic clearance rate of aldosterone was not statistically different between Brattleboro and Long-Evans rats, suggesting that the in vivo production rate of aldosterone was reduced by half in DI rats. Conversely, the basal in vitro production of aldosterone by adrenal tissue was similar in the two groups of rats. The reason for impairment of the in vivo production of aldosterone by Brattleboro rats congenitally lacking vasopressin is discussed. It is suggested that despite possibly indirect influence on the factors involved in the control of aldosterone secretion, mainly ACTH and potassium, vasopressin effects might occur in situ on the adrenal glomerulosa cells.
对患有遗传性尿崩症（DI）的Brattleboro雄性大鼠以及作为对照的Long-Evans雄性大鼠（LE），测定了血浆醛固酮浓度、代谢清除率以及体外肾上腺醛固酮生成情况。DI大鼠的血浆醛固酮浓度显著低于LE大鼠（-48.3%）。Brattleboro大鼠和Long-Evans大鼠之间醛固酮的代谢清除率无统计学差异，这表明DI大鼠体内醛固酮生成率降低了一半。相反，两组大鼠肾上腺组织醛固酮的基础体外生成情况相似。讨论了先天性缺乏血管加压素的Brattleboro大鼠体内醛固酮生成受损的原因。有人提出，尽管血管加压素可能对参与醛固酮分泌控制的因素（主要是促肾上腺皮质激素和钾）有间接影响，但其作用可能在肾上腺球状带细胞原位发生。
