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[顺铂外淋巴灌注对豚鼠耳蜗电位的影响]

[Effects of perilymphatic perfusion with cisplatin on the cochlear potential in guinea pigs].

作者信息

Wu D Z

机构信息

Shuguang Hospital, Shanghai College of Traditional Chinese Medicine.

出版信息

Zhonghua Er Bi Yan Hou Ke Za Zhi. 1990 Aug;25(4):202-4, 254.

PMID:2076322
Abstract

The effects of three concentrations of cisplatin, administered by acute perilymphatic perfusion on the endocochlear potential (EP) and the cochlear microphonic potential (CM) of the guinea pig cochleae, at 1 kHz are reported. No change in EP magnitude was discovered and a concentration-dependent reduction in CM amplitude occurred during 60 minutes' perfusion period. The results suggest that cisplatin-induced hearing loss is not necessarily progressive degradation of EP.

摘要

报道了通过急性外淋巴灌注给予三种浓度顺铂对豚鼠耳蜗在1kHz时的内淋巴电位（EP）和耳蜗微音电位（CM）的影响。在60分钟的灌注期内，未发现EP幅度有变化，而CM幅度出现了浓度依赖性降低。结果表明，顺铂诱导的听力损失不一定是EP的进行性退化。

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