Kambara H, Mohiuddin I H, Tamaki N, Fudo T, Hayashi M, Nohara R, Konishi J, Kawai C
Department of Internal Medicine, Kyoto University, Japan.
Cardiovasc Drugs Ther. 1990 Aug;4 Suppl 5:919-22. doi: 10.1007/BF02018293.
The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine administration. The heart rate increased and the resting systolic blood pressure decreased significantly with nifedipine. The end-diastolic and end-systolic volumes during exercise were significantly reduced and EF increased during exercise after nifedipine administration. These salutary hemodynamic responses of nifedipine appear to be beneficial for patients with effort angina pectoris.
采用动态放射性核素探测器（VEST）对17例冠心病患者评估硝苯地平对左心室功能的影响。在口服10mg硝苯地平前及给药后30分钟，于静息和直立自行车测力计运动期间连续记录血流动力学数据。硝苯地平使心率增加，静息收缩压显著降低。给药后运动期间的舒张末期和收缩末期容积显著减小，射血分数增加。硝苯地平这些有益的血流动力学反应似乎对劳力性心绞痛患者有益。
