Ross W B, Yap P L
University Department of Surgery, Edinburgh, UK.
Blood Rev. 1990 Dec;4(4):252-8. doi: 10.1016/0268-960x(90)90005-d.
During the last two decades it has been shown that blood transfusion enhances renal allograft survival. Recently, the introduction of cyclosporin A as the leading immunosuppressive agent has generally improved results and the relevance of blood transfusion to organ transplantation is now questioned. This review summarises the vast amount of knowledge on the 'blood transfusion effect in renal transplantation', and we cite important clinical studies of this topic to illustrate the various theories regarding the immune mechanisms responsible for these effects. We draw attention to the other immunomodulatory properties of blood transfusion which may be related to those associated with transplantation. In particular, we examine the possibility that perioperative blood transfusion may have a detrimental effect on the survival of cancer patients.
在过去二十年中，已表明输血可提高肾移植存活率。最近，作为主要免疫抑制剂的环孢素A的引入总体上改善了治疗效果，输血与器官移植的相关性如今受到质疑。本综述总结了关于“输血在肾移植中的作用”的大量知识，我们引用该主题的重要临床研究来说明关于这些作用的免疫机制的各种理论。我们提请注意输血的其他免疫调节特性，这些特性可能与那些与移植相关的特性有关。特别是，我们研究围手术期输血可能对癌症患者存活产生不利影响的可能性。
