钾通道阻断对大鼠离体气管非特异性气道高反应性的诱导作用
Induction of non-specific airway hyperreactivity by potassium channel blockade in rat isolated trachea.
作者信息
Chand N, Diamantis W, Sofia R D
机构信息
Wallace Laboratories, Division of Carter-Wallace, Inc., Cranbury, New Jersey 08512.
出版信息
Br J Pharmacol. 1990 Nov;101(3):541-4. doi: 10.1111/j.1476-5381.1990.tb14117.x.
Abstract
- The exposure of rat isolated tracheal segment to the K(+)-channel inhibitor tetraethylammonium (TEA, 10 mM) for a period of 10-15 min generally produced little or no contractile response. 2. Cooling (10 C) provocation alone usually produced small (10 +/- 3% acetylcholine maximum) contractile responses. 3. In the presence of TEA (10 mM, 10-15 min exposure), rat trachea exhibited airway hyperreactivity to acetylcholine, 5-hydroxytryptamine (5-HT) and cooling. It also increased the peak tension induced by 5-HT. 4. TEA-induced airway hyperreactivity to cooling was significantly inhibited in Ca2(+)-free Krebs solution suggesting an important role for extracellular Ca2+ influx. 5. We conclude that the blockade of potassium channels with TEA induces non-specific airway hyperreactivity to cooling, 5-HT and acetylcholine in rat isolated tracheal segments.
摘要
- 将大鼠离体气管段暴露于钾通道抑制剂四乙铵（TEA，10 mM）10 - 15分钟，通常产生很少或没有收缩反应。2. 单独冷却（10℃）刺激通常产生小的（乙酰胆碱最大反应的10±3%）收缩反应。3. 在存在TEA（10 mM，暴露10 - 15分钟）的情况下，大鼠气管对乙酰胆碱、5-羟色胺（5-HT）和冷却表现出气道高反应性。它还增加了5-HT诱导的峰值张力。4. 在无钙的Krebs溶液中，TEA诱导的对冷却的气道高反应性被显著抑制，表明细胞外钙内流起重要作用。5. 我们得出结论，用TEA阻断钾通道会在大鼠离体气管段中诱导对冷却、5-HT和乙酰胆碱的非特异性气道高反应性。
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