Sun Y
Institute of Virology, Hubei Medical College, Wuhan.
Zhonghua Zhong Liu Za Zhi. 1990 Nov;12(6):401-3.
The effect of human semen and culture fluid of bacteria (SB) isolated from the cervix of carcinoma patients on the induction of cervical carcinoma by 20-methylcholanthrene (MCA) in mice was studied. It was found that cervical carcinoma could be induced by SB with an induction rate of 12%. That by MCA alone was 11.8% whereas the SB positive for inducing EB virus EA in Raji cells used in combination with MCA gave an induction rate of 54.2%. The experimental results indicated that SB was both carcinogenic and tumor promoting. The possible mechanism of action of SB is discussed.
研究了人精液以及从宫颈癌患者宫颈分离出的细菌培养液（SB）对20-甲基胆蒽（MCA）诱发小鼠宫颈癌的影响。发现SB可诱发宫颈癌，诱发率为12%。单独使用MCA的诱发率为11.8%，而在Raji细胞中能诱导EB病毒EA阳性的SB与MCA联合使用时，诱发率为54.2%。实验结果表明，SB既有致癌作用又有促癌作用。并对SB可能的作用机制进行了讨论。
